ID   Penl1
AC   CVCL_VF93
DR   cancercelllines; CVCL_VF93
DR   Cosmic; 2806800
DR   Cosmic; 2806954
DR   Wikidata; Q54946918
RX   PubMed=27351128;
RX   PubMed=28344882;
RX   PubMed=29880898;
CC   Population: Chinese.
CC   Doubling time: ~27 hours (PubMed=27351128); 28.16 hours (PubMed=29880898).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Unspecified (PubMed=29880898).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro72Arg (c.215C>G); ClinVar=VCV000012351; Zygosity=Unspecified (PubMed=27351128; PubMed=29880898).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg283Pro (c.848G>C); ClinVar=VCV000486555; Zygosity=Unspecified (PubMed=27351128; PubMed=29880898).
CC   Omics: Genome sequenced.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
ST   Source(s): PubMed=27351128; PubMed=29880898
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 9,12
ST   D16S539: 11,12
ST   D5S818: 13
ST   D7S820: 11
ST   TH01: 7,9
ST   TPOX: 8,11
ST   vWA: 18
DI   NCIt; C7729; Squamous cell carcinoma of the penis
DI   ORDO; Orphanet_398058; Squamous cell carcinoma of the penis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   41Y
CA   Cancer cell line
DT   Created: 14-05-18; Last updated: 19-12-24; Version: 14
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RX   PubMed=27351128; DOI=10.18632/oncotarget.10098; PMCID=PMC5239507;
RA   Chen J.-P., Yao K., Li Z.-S., Deng C.-Z., Wang L.-J., Yu X.-S.,
RA   Liang P.-L., Xie Q.-K., Chen P., Qin Z.-K., Ye Y.-L., Liu Z.-W.,
RA   Zhou F.-J., Zhang Z.-F., Han H.;
RT   "Establishment and characterization of a penile cancer cell line,
RT   penl1, with a deleterious TP53 mutation as a paradigm of HPV-negative
RT   penile carcinogenesis.";
RL   Oncotarget 7:51687-51698(2016).
//
RX   PubMed=28344882; DOI=10.1080/2162402X.2016.1269047; PMCID=PMC5353932;
RA   Deng C.-Z., Li Z.-S., Guo S.-J., Chen P., Chen X.-F., Zhou Q.-H.,
RA   Chen J.-P., Yu X.-S., Wu X.-L., Ma W.-J., Xie Q.-K., Ye Y.-L.,
RA   Li Y.-H., Qin Z.-K., Liu Z.-W., Liu R.-Y., Zhang Z.-F., Yao K., Han H.,
RA   Zhou F.-J.;
RT   "Tumor PD-L1 expression is correlated with increased TILs and poor
RT   prognosis in penile squamous cell carcinoma.";
RL   OncoImmunology 6:e1269047.1-e1269047.8(2017).
//
RX   PubMed=29880898; DOI=10.1038/s41419-018-0736-1; PMCID=PMC5992159;
RA   Zhou Q.-H., Deng C.-Z., Li Z.-S., Chen J.-P., Yao K., Huang K.-B.,
RA   Liu T.-Y., Liu Z.-W., Qin Z.-K., Zhou F.-J., Huang W., Han H., Liu R.-Y.;
RT   "Molecular characterization and integrative genomic analysis of a
RT   panel of newly established penile cancer cell lines.";
RL   Cell Death Dis. 9:684.1-684.14(2018).
//