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Cellosaurus Hep-G2 A-1 (CVCL_VA32)

[Text version]
Cell line name Hep-G2 A-1
Synonyms A-1
Accession CVCL_VA32
Resource Identification Initiative To cite this cell line use: Hep-G2 A-1 (RRID:CVCL_VA32)
Comments Population: Caucasian.
Virology: Contains 2 head to tails stably integrated hepatitis B virus (HBV) of the A-genotype.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=29481805; DOI=10.1016/j.bbrc.2018.02.175
Ogura N., Ogawa K., Watashi K., Ito T., Wakita T.
Novel stable HBV producing cell line systems for expression and screening antiviral inhibitor of hepatitis B virus in human hepatoma cell line.
Biochem. Biophys. Res. Commun. 498:64-71(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VA32
Encyclopedic resources Wikidata; Q54882779
Entry history
Entry creation14-May-2018
Last entry update19-Dec-2024
Version number15