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Cellosaurus Tong/HCC (CVCL_V640)

[Text version]
Cell line name Tong/HCC
Synonyms Tong; TONG; TONG/PHC; TONG PHC
Accession CVCL_V640
Resource Identification Initiative To cite this cell line use: Tong/HCC (RRID:CVCL_V640)
Comments Part of: Liver Cancer Model Repository (LIMORE).
Population: Caucasian; Italian.
Doubling time: ~50 hours (PubMed=2445644); 26.71 hours (PubMed=31378681).
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Omics: Genome sequenced.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:11110; ARID1A; Simple; c.5125-1G>T; Zygosity=Unspecified; Note=Splice acceptor mutation (PubMed=31378681).
  • Mutation; HGNC; HGNC:1058; BLM; Simple; p.Leu148Ter (c.443T>A); Zygosity=Unspecified (PubMed=31378681).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31378681).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro72Arg (c.215C>G); ClinVar=VCV000012351; Zygosity=Unspecified (PubMed=31378681).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
STR profile Source(s): PubMed=31378681

Markers:
AmelogeninX
CSF1PO11,12
D5S81812
D7S8208,12
D13S31714
D16S5399
TH018,10
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=3023526; DOI=10.1099/0022-1317-67-11-2315
Aspinall S., Alexander J.J., Bos P.
Comparative expression of hepatitis B virus antigens in several cell model systems.
J. Gen. Virol. 67:2315-2323(1986)

DOI=10.1007/978-4-431-68349-0_4
Alexander J.J.
Human hepatoma cell lines.
(In book chapter) Neoplasms of the liver; Okuda K., Ishak K.G. (eds.); pp.47-56; Springer; Tokyo; Japan (1987)

PubMed=2445644; DOI=10.1002/hep.1840070619
Stevenson D., Lin J.-H., Tong M.J., Marshall G.J.
Characteristics of a cell line (Tong/HCC) established from a human hepatocellular carcinoma.
Hepatology 7:1291-1295(1987)

PubMed=8224613; DOI=10.1096/fasebj.7.14.8224613
Puisieux A., Galvin K., Troalen F., Bressac B., Marcais C., Galun E., Ponchel F., Yakicier C., Ji J.-W., Ozturk M.
Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines.
FASEB J. 7:1407-1413(1993)

PubMed=8050184; DOI=10.1111/j.1365-2249.1994.tb06089.x; PMCID=PMC1534706
Wadee A.A., Paterson A., Coplan K.A., Reddy S.G.
HLA expression in hepatocellular carcinoma cell lines.
Clin. Exp. Immunol. 97:328-333(1994)

PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001; PMCID=PMC7505724
Qiu Z.-X., Li H., Zhang Z.-T., Zhu Z.-F., He S., Wang X.-J., Wang P.-C., Qin J.-J., Zhuang L.-P., Wang W., Xie F.-B., Gu Y., Zou K.-K., Li C., Li C., Wang C.-H., Cen J., Chen X.-T., Shu Y.-J., Zhang Z., Sun L.-L., Min L.-H., Fu Y., Huang X.-W., Lv H., Zhou H., Ji Y., Zhang Z.-G., Meng Z.-Q., Shi X.-L., Zhang H.-B., Li Y.-X., Hui L.-J.
A pharmacogenomic landscape in human liver cancers.
Cancer Cell 36:179-193.e11(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_V640
LIMORE; Tong
Encyclopedic resources Wikidata; Q54972784
Gene expression databases GEO; GSM2551595
Entry history
Entry creation16-Apr-2014
Last entry update19-Dec-2024
Version number18