ID   F5
AC   CVCL_V616
DR   BTO; BTO:0004530
DR   BioGRID_ORCS_Cell_line; 434
DR   cancercelllines; CVCL_V616
DR   Cell_Model_Passport; SIDM01497
DR   DepMap; ACH-001067
DR   PharmacoDB; F5_364_2019
DR   Progenetix; CVCL_V616
DR   Wikidata; Q54833148
RX   PubMed=7542695;
RX   PubMed=7585498;
RX   PubMed=25984343;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=34850056;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Doubling time: 46 hours (PubMed=25984343); 1 day (PubMed=34850056).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Unspecified (DepMap=ACH-001067).
CC   Omics: Deep exome analysis.
CC   Genome ancestry: African=2.76%; Native American=0%; East Asian, North=3.58%; East Asian, South=0%; South Asian=0%; European, North=60.4%; European, South=33.25% (PubMed=30894373).
DI   NCIt; C3230; Meningioma
DI   ORDO; Orphanet_2495; Meningioma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 16-04-14; Last updated: 02-05-24; Version: 17
//
RX   PubMed=7542695; DOI=10.1007/BF01058456;
RA   Yazaki T., Takamiya Y., Costello P.C., Mineta T., Menon A.G.,
RA   Rabkin S.D., Martuza R.L.;
RT   "Inhibition of angiogenesis and growth of human non-malignant and
RT   malignant meningiomas by TNP-470.";
RL   J. Neurooncol. 23:23-29(1995).
//
RX   PubMed=7585498;
RA   Yazaki T., Manz H.J., Rabkin S.D., Martuza R.L.;
RT   "Treatment of human malignant meningiomas by G207, a
RT   replication-competent multimutated herpes simplex virus 1.";
RL   Cancer Res. 55:4752-4756(1995).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35;
RA   Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S.,
RA   East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H.,
RA   Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M.,
RA   Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S.,
RA   Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D.,
RA   Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C.,
RA   Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P.,
RA   Golub T.R., Root D.E., Hahn W.C.;
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035-140035(2014).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=34850056; DOI=10.1093/jnen/nlab111;
RA   Uhlmann E.J., Rabinovsky R., Varma H., El Fatimy R., Kasper E.M.,
RA   Moore J.M., Vega R.A., Thomas A.J., Alterman R.L., Stippler M.,
RA   Anderson M.P., Uhlmann E.N., Kipper F.C., Krichevsky A.M.;
RT   "Tumor-derived cell culture model for the investigation of meningioma
RT   biology.";
RL   J. Neuropathol. Exp. Neurol. 80:1117-1124(2021).
//