ID   SLR24
AC   CVCL_V610
SY   SLR 24
DR   BioSample; SAMN10988394
DR   cancercelllines; CVCL_V610
DR   Cell_Model_Passport; SIDM01339
DR   Cell_Model_Passport; SIDM01919
DR   Cosmic; 2520643
DR   DepMap; ACH-000272
DR   GEO; GSM374471
DR   PharmacoDB; SLR24_1424_2019
DR   Progenetix; CVCL_V610
DR   Wikidata; Q54954875
RX   PubMed=12907621;
RX   PubMed=19470766;
RX   PubMed=22949125;
RX   PubMed=25984343;
RX   PubMed=30894373;
RX   PubMed=31068700;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a RCC4 derivative (ICLAC).
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00574.
CC   Population: Caucasian.
CC   Doubling time: 30 hours (PubMed=25984343).
CC   Sequence variation: Mutation; HGNC; HGNC:12687; VHL; Simple; p.Ser65Trp (c.194C>G); ClinVar=VCV000043597; Zygosity=Hemizygous (DepMap=ACH-000272).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; shRNA library screening.
CC   Genome ancestry: African=0.24%; Native American=0%; East Asian, North=2.8%; East Asian, South=0%; South Asian=0%; European, North=55.96%; European, South=41% (PubMed=30894373).
CC   Miscellaneous: STR profile from personal communication of von Teichman, Adriana.
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
ST   Source(s): Direct_author_submission
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 11,12
ST   D16S539: 11
ST   D21S11: 30
ST   D5S818: 12
ST   D7S820: 8
ST   TH01: 9.3
ST   TPOX: 11
ST   vWA: 16
DI   NCIt; C4033; Clear cell renal cell carcinoma
DI   ORDO; Orphanet_319276; Clear cell renal carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0498 ! RCC4
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 16-04-14; Last updated: 10-04-25; Version: 21
//
RX   PubMed=19470766; DOI=10.1158/0008-5472.CAN-09-0146; PMCID=PMC2745239;
RA   Beroukhim, Rameen
RA   Brunet, Jean-Philippe
RA   Di Napoli, Arianna
RA   Mertz, Kirsten D.
RA   Seeley, Apryle
RA   Pires, Maira M.
RA   Linhart, David
RA   Worrell, Robert A.
RA   Moch, Holger
RA   Rubin, Mark A.
RA   Sellers, William Raj
RA   Meyerson, Matthew Langer
RA   Linehan, William Marston
RA   Kaelin, William George Jr.
RA   Signoretti, Sabina
RT   "Patterns of gene expression and copy-number alterations in von-Hippel
RT   Lindau disease-associated and sporadic clear cell carcinoma of the
RT   kidney.";
RL   Cancer Res. 69:4674-4681(2009).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=12907621;
RA   Tatsumi, Tomohide
RA   Herrem, Christopher J.
RA   Olson, William C.
RA   Finke, James H.
RA   Bukowski, Ronald M.
RA   Kinch, Michael Scott
RA   Ranieri, Elena
RA   Storkus, Walter J.
RT   "Disease stage variation in CD4+ and CD8+ T-cell reactivity to the
RT   receptor tyrosine kinase EphA2 in patients with renal cell
RT   carcinoma.";
RL   Cancer Res. 63:4481-4489(2003).
//
RX   PubMed=22949125; DOI=10.1002/ijc.27822;
RA   Pawlowski, Rafal
RA   Muhl, Sarah M.
RA   Sulser, Tullio
RA   Krek, Wilhelm
RA   Moch, Holger
RA   Schraml, Peter
RT   "Loss of PBRM1 expression is associated with renal cell carcinoma
RT   progression.";
RL   Int. J. Cancer 132:E11-E17(2013).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652;
RA   Cowley, Glenn S.
RA   Weir, Barbara A.
RA   Vazquez, Francisca
RA   Tamayo, Pablo
RA   Scott, Justine A.
RA   Rusin, Scott
RA   East-Seletsky, Alexandra
RA   Ali, Levi D.
RA   Gerath, William F.J.
RA   Pantel, Sarah E.
RA   Lizotte, Patrick Hall
RA   Jiang, Guo-Zhi
RA   Hsiao, Jessica
RA   Tsherniak, Aviad
RA   Dwinell, Elizabeth
RA   Aoyama, Simon
RA   Okamoto, Michael
RA   Harrington, William
RA   Gelfand, Ellen T.
RA   Green, Thomas M.
RA   Tomko, Mark J.
RA   Gopal, Shuba
RA   Wong, Terence C.
RA   Li, Hu-Bo
RA   Howell, Sara
RA   Stransky, Nicolas
RA   Liefeld, Ted
RA   Jang, Dongkeun
RA   Bistline, Jonathan
RA   Meyers, Barbara Hill
RA   Armstrong, Scott Allen
RA   Anderson, Kenneth Carl
RA   Stegmaier, Kimberly
RA   Reich, Michael
RA   Pellman, David
RA   Boehm, Jesse S.
RA   Mesirov, Jill P.
RA   Golub, Todd Robert
RA   Root, David E.
RA   Hahn, William Chun
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035.1-140035.12(2014).
//