ID   SLR24
AC   CVCL_V610
SY   SLR 24
DR   BioSample; SAMN10988394
DR   cancercelllines; CVCL_V610
DR   Cell_Model_Passport; SIDM01339
DR   Cell_Model_Passport; SIDM01919
DR   Cosmic; 2520643
DR   DepMap; ACH-000272
DR   GEO; GSM374471
DR   PharmacoDB; SLR24_1424_2019
DR   Progenetix; CVCL_V610
DR   Wikidata; Q54954875
RX   PubMed=12907621;
RX   PubMed=19470766;
RX   PubMed=22949125;
RX   PubMed=25984343;
RX   PubMed=30894373;
RX   PubMed=31068700;
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a RCC4 derivative (ICLAC).
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00574.
CC   Population: Caucasian.
CC   Doubling time: 30 hours (PubMed=25984343).
CC   Sequence variation: Mutation; HGNC; 12687; VHL; Simple; p.Ser65Trp (c.194C>G); ClinVar=VCV000043597; Zygosity=Hemizygous (DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: shRNA library screening.
CC   Genome ancestry: African=0.24%; Native American=0%; East Asian, North=2.8%; East Asian, South=0%; South Asian=0%; European, North=55.96%; European, South=41% (PubMed=30894373).
CC   Miscellaneous: STR profile from personal communication of von Teichman A.
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
ST   Source(s): Direct_author_submission
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 11,12
ST   D16S539: 11
ST   D21S11: 30
ST   D5S818: 12
ST   D7S820: 8
ST   TH01: 9.3
ST   TPOX: 11
ST   vWA: 16
DI   NCIt; C4033; Clear cell renal cell carcinoma
DI   ORDO; Orphanet_319276; Clear cell renal carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0498 ! RCC4
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 16-04-14; Last updated: 05-10-23; Version: 17
//
RX   PubMed=12907621;
RA   Tatsumi T., Herrem C.J., Olson W.C., Finke J.H., Bukowski R.M.,
RA   Kinch M.S., Ranieri E., Storkus W.J.;
RT   "Disease stage variation in CD4+ and CD8+ T-cell reactivity to the
RT   receptor tyrosine kinase EphA2 in patients with renal cell
RT   carcinoma.";
RL   Cancer Res. 63:4481-4489(2003).
//
RX   PubMed=19470766; DOI=10.1158/0008-5472.CAN-09-0146;
RA   Beroukhim R., Brunet J.-P., Di Napoli A., Mertz K.D., Seeley A.,
RA   Pires M.M., Linhart D., Worrell R.A., Moch H., Rubin M.A.,
RA   Sellers W.R., Meyerson M.L., Linehan W.M., Kaelin W.G. Jr.,
RA   Signoretti S.;
RT   "Patterns of gene expression and copy-number alterations in von-Hippel
RT   Lindau disease-associated and sporadic clear cell carcinoma of the
RT   kidney.";
RL   Cancer Res. 69:4674-4681(2009).
//
RX   PubMed=22949125; DOI=10.1002/ijc.27822;
RA   Pawlowski R., Muhl S.M., Sulser T., Krek W., Moch H., Schraml P.;
RT   "Loss of PBRM1 expression is associated with renal cell carcinoma
RT   progression.";
RL   Int. J. Cancer 132:E11-E17(2013).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35;
RA   Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S.,
RA   East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H.,
RA   Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M.,
RA   Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S.,
RA   Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D.,
RA   Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C.,
RA   Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P.,
RA   Golub T.R., Root D.E., Hahn W.C.;
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035-140035(2014).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//