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Cellosaurus SNU-C5/IRT-R (CVCL_V483)

[Text version]
Cell line name SNU-C5/IRT-R
Accession CVCL_V483
Resource Identification Initiative To cite this cell line use: SNU-C5/IRT-R (RRID:CVCL_V483)
Comments Population: Korean.
Selected for resistance to: ChEBI; CHEBI_80630; Irinotecan (Camptothecin-11; CPT-11).
Derived from site: In situ; Cecum; UBERON=UBERON_0001153.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val218Leu (c.652G>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Heterozygous (from parent cell line).
Disease Cecum adenocarcinoma (NCIt: C5543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5112 (SNU-C5)
Sex of cell Female
Age at sampling 77Y
Category Cancer cell line
Publications

PubMed=17845510; DOI=10.1111/j.1742-7843.2007.00115.x
Jung G.-R., Kim K.-J., Choi C.-H., Lee T.-B., Han S.I., Han H.-K., Lim S.-C.
Effect of betulinic acid on anticancer drug-resistant colon cancer cells.
Basic Clin. Pharmacol. Toxicol. 101:277-285(2007)

Cross-references
Cell line databases/resources cancercelllines; CVCL_V483
Encyclopedic resources Wikidata; Q54955298
Entry history
Entry creation16-Apr-2014
Last entry update19-Dec-2024
Version number11