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Cellosaurus HCC827ER (CVCL_V408)

[Text version]
Cell line name HCC827ER
Accession CVCL_V408
Resource Identification Initiative To cite this cell line use: HCC827ER (RRID:CVCL_V408)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_114785; Erlotinib.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
Publications

PubMed=21062933; DOI=10.1158/1078-0432.CCR-10-1371
Suda K., Murakami I., Katayama T., Tomizawa K., Osada H., Sekido Y., Maehara Y., Yatabe Y., Mitsudomi T.
Reciprocal and complementary role of MET amplification and EGFR T790M mutation in acquired resistance to kinase inhibitors in lung cancer.
Clin. Cancer Res. 16:5489-5498(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_V408
Encyclopedic resources Wikidata; Q54881810
Entry history
Entry creation16-Apr-2014
Last entry update19-Dec-2024
Version number15