Cellosaurus cell line MDA-MB-231-MEK-R (CVCL

Cellosaurus MDA-MB-231-MEK-R (CVCL_V403)

Cross-references
Cell line name	MDA-MB-231-MEK-R
Accession	CVCL_V403
Resource Identification Initiative	To cite this cell line use: MDA-MB-231-MEK-R (RRID:CVCL_V403)
Comments	Group: Triple negative breast cancer (TNBC) cell line. Population: Caucasian. Selected for resistance to: ChEBI; CHEBI:88249; 391210-10-9 (PD0325901). Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line). Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line). Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease	Breast adenocarcinoma (NCIt: C5214)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0062 (MDA-MB-231)
Sex of cell	Female
Age at sampling	51Y
Category	Cancer cell line
Publications	PubMed=22402123; DOI=10.1158/1535-7163.MCT-11-1010 Hatzivassiliou G., Liu B., O'Brien C., Spoerke J.M., Hoeflich K.P., Haverty P.M., Soriano R., Forrest W.F., Heldens S., Chen H.-F., Toy K., Ha C., Zhou W., Song K., Friedman L.S., Amler L.C., Hampton G.M., Moffat J., Belvin M.P., Lackner M.R. ERK inhibition overcomes acquired resistance to MEK inhibitors. Mol. Cancer Ther. 11:1143-1154(2012)
Cell line databases/resources	cancercelllines; CVCL_V403
Encyclopedic resources	Wikidata; Q54904605
Polymorphism and mutation databases	Cosmic; 1927243
Entry history
Entry creation	16-Apr-2014
Last entry update	05-Oct-2023
Version number	20