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Cellosaurus AND-1 MLLAF4 FLT3 ITD (CVCL_V164)

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Cell line name AND-1 MLLAF4 FLT3 ITD
Accession CVCL_V164
Resource Identification Initiative To cite this cell line use: AND-1 MLLAF4 FLT3 ITD (RRID:CVCL_V164)
Comments Part of: Spanish Stem Cell Bank (Banco Nacional de Lineas Celulares) collection.
From: Centre for Genomics and Oncological Research (GENYO); Granada; Spain.
Characteristics: Transduced with both a pRRL-EF1a-MLLAF4-PGK-Neo and a pRRL-EF1a-FLT3 ITD-PGK-GFP constructs.
Karyotypic information: 46,XY,+i(7)p(11),-7 (BNLC).
Transfected with: HGNC; 7135; AFF1 (KMT2-AFF1/MLL-AF4 fusion).
Transfected with: HGNC; 7132; KMT2A (KMT2-AFF1/MLL-AF4 fusion).
Transfected with: HGNC; 3765; FLT3 (with ITD).
Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
Cell type: Embryonic stem cell; CL=CL_0002322.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B526 (AND-1)
Sex of cell Male
Age at sampling Blastocyst stage
Category Embryonic stem cell
Web pages https://www.isciii.es/QueHacemos/Servicios/BIOBANCOS/BNLC/Lists/Lneas%20embrionarias/Attachments/37/Caracteristicas%20-%20Dossier_AND1-MLLAF4-FLT3-ITD.pdf

PubMed=23479570; DOI=10.1182/blood-2012-11-470146
Bueno C., Ayllon V., Montes R., Navarro-Montero O., Ramos-Mejia V., Real P.J., Romero-Moya D., Arauzo-Bravo M.J., Menendez P.
FLT3 activation cooperates with MLL-AF4 fusion protein to abrogate the hematopoietic specification of human ESCs.
Blood 121:3867-3878(2013)

Cell line databases/resources ISCR; 2207
Encyclopedic resources Wikidata; Q54749924
Entry history
Entry creation16-Apr-2014
Last entry update30-Jan-2024
Version number10