Cellosaurus cell line LiF-EP/TERT-1 (CVCL

Cellosaurus LiF-EP/TERT-1 (CVCL_UZ59)

Cross-references
Cell line name	LiF-EP/TERT-1
Accession	CVCL_UZ59
Resource Identification Initiative	To cite this cell line use: LiF-EP/TERT-1 (RRID:CVCL_UZ59)
Comments	Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT. Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003. Cell type: Keratinocyte; CL=CL_0000312.
Sequence variations	Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Heterozygous (PubMed=10648628). Mutation; HGNC; HGNC:11998; TP53; Simple; c.993+1delG (IVS9+1delG); ClinVar=VCV000428898; Zygosity=Heterozygous; Note=Splice donor mutation (PubMed=10980596).
Disease	Li-Fraumeni syndrome (NCIt: C3476) Li-Fraumeni syndrome (ORDO: Orphanet_524)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_UZ58 (LiF-EP)
Sex of cell	Female
Age at sampling	60Y
Category	Telomerase immortalized cell line
Web pages	https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
Publications	PubMed=10648628; DOI=10.1128/mcb.20.4.1436-1447.2000; PMCID=PMC85304 Dickson M.A., Hahn W.C., Ino Y., Ronfard V., Wu J.Y., Weinberg R.A., Louis D.N., Li F.P., Rheinwald J.G. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol. Cell. Biol. 20:1436-1447(2000) PubMed=10980596; DOI=10.1038/sj.onc.1203758 Verselis S.J., Rheinwald J.G., Fraumeni J.F. Jr., Li F.P. Novel p53 splice site mutations in three families with Li-Fraumeni syndrome. Oncogene 19:4230-4235(2000)
Encyclopedic resources	Wikidata; Q95982192
Entry history
Entry creation	25-Feb-2019
Last entry update	19-Dec-2024
Version number	9