ID   LiF-EP
AC   CVCL_UZ58
DR   Wikidata; Q95982190
RX   PubMed=10648628;
RX   PubMed=10980596;
WW   https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
CC   Senescence: Senesces at ~35 PDL (PubMed=10648628).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.993+1delG (IVS9+1delG); ClinVar=VCV000428898; Zygosity=Heterozygous; Note=Splice donor mutation (PubMed=10980596).
CC   Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
CC   Cell type: Keratinocyte; CL=CL_0000312.
DI   NCIt; C3476; Li-Fraumeni syndrome
DI   ORDO; Orphanet_524; Li-Fraumeni syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   60Y
CA   Finite cell line
DT   Created: 25-02-19; Last updated: 19-12-24; Version: 9
//
RX   PubMed=10648628; DOI=10.1128/mcb.20.4.1436-1447.2000; PMCID=PMC85304;
RA   Dickson M.A., Hahn W.C., Ino Y., Ronfard V., Wu J.Y., Weinberg R.A.,
RA   Louis D.N., Li F.P., Rheinwald J.G.;
RT   "Human keratinocytes that express hTERT and also bypass a
RT   p16(INK4a)-enforced mechanism that limits life span become immortal yet
RT   retain normal growth and differentiation characteristics.";
RL   Mol. Cell. Biol. 20:1436-1447(2000).
//
RX   PubMed=10980596; DOI=10.1038/sj.onc.1203758;
RA   Verselis S.J., Rheinwald J.G., Fraumeni J.F. Jr., Li F.P.;
RT   "Novel p53 splice site mutations in three families with Li-Fraumeni
RT   syndrome.";
RL   Oncogene 19:4230-4235(2000).
//