ID   Ocy454
AC   CVCL_UW31
SY   OCY454
DR   Wikidata; Q98128331
RX   PubMed=25953900;
RX   PubMed=30977540;
WW   https://www.csr-mgh.org/wp-content/uploads/2017/04/OCY454-1.pdf
CC   Characteristics: Displays a dendritic morphology similar to other osteocytic cell lines.
CC   Characteristics: Expresses GFP Topaz under the control of the Dmp1 promoter.
CC   Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Genetic integration: Method=Transgenic mouse; Gene=FPbase; SY6TH; Topaz (Note=Green/yellow fluorescent protein derived from GFP).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
CC   Derived from site: In situ; Bone, long bone; UBERON=UBERON_0002495.
CC   Cell type: Osteocyte; CL=CL_0000137.
CC   Breed/subspecies: C57BL/6-Tg(Dmp1-Topaz)1Ikal/J x (CBA/Ca x C57BL/10)Tg(H2Kb-tsA58) Immortomouse.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Sex unspecified
AG   4W
CA   Conditionally immortalized cell line
DT   Created: 25-02-19; Last updated: 10-09-24; Version: 9
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RX   PubMed=25953900; DOI=10.1074/jbc.M114.628313; PMCID=PMC4505423;
RA   Spatz J.M., Wein M.N., Gooi J.H., Qu Y.-L., Garr J.L., Liu S.,
RA   Barry K.J., Uda Y.-H., Lai F., Dedic C., Balcells-Camps M.,
RA   Kronenberg H.M., Babij P., Pajevic P.D.;
RT   "The Wnt inhibitor sclerostin is up-regulated by mechanical unloading
RT   in osteocytes in vitro.";
RL   J. Biol. Chem. 290:16744-16758(2015).
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RX   PubMed=30977540; DOI=10.1002/jor.24302;
RA   Xu L.-C.H., Shao H., Ma Y.-H.V., You L.-D.;
RT   "OCY454 osteocytes as an in vitro cell model for bone remodeling under
RT   mechanical loading.";
RL   J. Orthop. Res. 37:1681-1689(2019).
//