ID   CNIO AA
AC   CVCL_UT97
SY   CNIO-AA
DR   cancercelllines; CVCL_UT97
DR   IARC_TP53; 24520
DR   Wikidata; Q93455932
RX   CelloPub=CLPUB00464;
RX   PubMed=16888811;
RX   PubMed=17431109;
RX   PubMed=24758355;
CC   Doubling time: 36 hours (PubMed=16888811).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (PubMed=16888811).
DI   NCIt; C3158; Leiomyosarcoma
DI   ORDO; Orphanet_64720; Leiomyosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 25-02-19; Last updated: 19-12-24; Version: 8
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RX   CelloPub=CLPUB00464;
RA   Moneo V.;
RT   "Generation of cellular tools for preclinical validation of antitumor
RT   compounds.";
RL   Thesis PhD (2009); Universidad Autonoma de Madrid; Madrid; Spain.
//
RX   PubMed=16888811; DOI=10.1002/jcb.21073;
RA   Moneo V., Serelde B.G., Fominaya J.M., Martinez-Leal J.F.,
RA   Blanco-Aparicio C., Romero L., Sanchez-Beato M., Cigudosa J.C.,
RA   Tercero J.C., Piris M.A., Jimeno J.M., Carnero A.;
RT   "Extreme sensitivity to Yondelis (Trabectedin, ET-743) in low passaged
RT   sarcoma cell lines correlates with mutated p53.";
RL   J. Cell. Biochem. 100:339-348(2007).
//
RX   PubMed=17431109; DOI=10.1158/1535-7163.MCT-06-0729;
RA   Moneo V., Serelde B.G., Leal J.F.M., Blanco-Aparicio C.,
RA   Diaz-Uriarte R., Aracil M., Tercero J.C., Jimeno J.M., Carnero A.;
RT   "Levels of p27(kip1) determine Aplidin sensitivity.";
RL   Mol. Cancer Ther. 6:1310-1316(2007).
//
RX   PubMed=24758355; DOI=10.1186/1471-2407-14-281; PMCID=PMC4023704;
RA   Moneo V., Serelde B.G., Blanco-Aparicio C., Diaz-Uriarte R.,
RA   Aviles P., Santamaria G., Tercero J.C., Cuevas C., Carnero A.;
RT   "Levels of active tyrosine kinase receptor determine the tumor
RT   response to Zalypsis.";
RL   BMC Cancer 14:281.1-281.10(2014).
//