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Cellosaurus HL-60 SN3 (CVCL_UM48)

[Text version]
Cell line name HL-60 SN3
Synonyms HL-60-SN3; HL60 SN3; HL60/SN3; SN3
Accession CVCL_UM48
Resource Identification Initiative To cite this cell line use: HL-60 SN3 (RRID:CVCL_UM48)
Comments Population: Caucasian.
Characteristics: The TP53 null parental cell line was transfected with a wild type TP53 sequence.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 11998; TP53.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
Publications

PubMed=8562479
Banerjee D., Lenz H.-J., Schnieders B., Manno D.J., Ju J.-F., Spears C.P., Hochhauser D., Danenberg K.D., Danenberg P.V., Bertino J.R.
Transfection of wild-type but not mutant p53 induces early monocytic differentiation in HL60 cells and increases their sensitivity to stress.
Cell Growth Differ. 6:1405-1413(1995)

PubMed=9607592
Ju J.-F., Banerjee D., Lenz H.-J., Danenberg K.D., Schmittgen T.C., Spears C.P., Schonthal A.H., Manno D.J., Hochhauser D., Bertino J.R., Danenberg P.V.
Restoration of wild-type p53 activity in p53-null HL-60 cells confers multidrug sensitivity.
Clin. Cancer Res. 4:1315-1322(1998)

Cross-references
Cell line databases/resources cancercelllines; CVCL_UM48
Encyclopedic resources Wikidata; Q94211503
Entry history
Entry creation25-Feb-2019
Last entry update10-Sep-2024
Version number11