Cellosaurus cell line HL-60 SCX3 (CVCL

Cellosaurus HL-60 SCX3 (CVCL_UM47)

Cross-references
Cell line name	HL-60 SCX3
Synonyms	HL60 SCX3; SCX3
Accession	CVCL_UM47
Resource Identification Initiative	To cite this cell line use: HL-60 SCX3 (RRID:CVCL_UM47)
Comments	Population: Caucasian. Characteristics: The TP53 null parental cell line was transfected with a mutated TP53 sequence. Genetic integration: Method=Transfection/transduction; Gene=HGNC; 11998; TP53 (Note=With p.Val143Ala). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations	Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease	Adult acute myeloid leukemia (NCIt: C9154) Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0002 (HL-60)
Sex of cell	Female
Age at sampling	36Y
Category	Cancer cell line
Publications	PubMed=8562479 Banerjee D., Lenz H.-J., Schnieders B., Manno D.J., Ju J.-F., Spears C.P., Hochhauser D., Danenberg K.D., Danenberg P.V., Bertino J.R. Transfection of wild-type but not mutant p53 induces early monocytic differentiation in HL60 cells and increases their sensitivity to stress. Cell Growth Differ. 6:1405-1413(1995) PubMed=9607592 Ju J.-F., Banerjee D., Lenz H.-J., Danenberg K.D., Schmittgen T.C., Spears C.P., Schonthal A.H., Manno D.J., Hochhauser D., Bertino J.R., Danenberg P.V. Restoration of wild-type p53 activity in p53-null HL-60 cells confers multidrug sensitivity. Clin. Cancer Res. 4:1315-1322(1998)
Cell line databases/resources	cancercelllines; CVCL_UM47
Encyclopedic resources	Wikidata; Q94211499
Entry history
Entry creation	25-Feb-2019
Last entry update	10-Sep-2024
Version number	11