ID   BT084
AC   CVCL_UK69
SY   BT84; BT-84
DR   Wikidata; Q93432808
RX   PubMed=26095605;
RX   PubMed=26245525;
RX   PubMed=27006494;
CC   Group: Cancer stem cell line.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=26095605).
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   67Y
CA   Cancer cell line
DT   Created: 25-02-19; Last updated: 29-06-23; Version: 7
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RX   PubMed=26095605; DOI=10.1016/j.stemcr.2015.05.010;
RA   Cusulin C., Chesnelong C., Bose P., Bilenky M., Kopciuk K., Chan J.A.W.,
RA   Cairncross J.G., Jones S.J.M., Marra M.A., Luchman H.A., Weiss S.;
RT   "Precursor states of brain tumor initiating cell lines are predictive
RT   of survival in xenografts and associated with glioblastoma
RT   subtypes.";
RL   Stem Cell Reports 5:1-9(2015).
//
RX   PubMed=26245525; DOI=10.1093/neuonc/nov143;
RA   Davis B., Shen Y.-Q., Poon C.C., Luchman H.A., Stechishin O.D.M.,
RA   Pontifex C.S., Wu W., Kelly J.J.P., Blough M.D.;
RT   "Comparative genomic and genetic analysis of glioblastoma-derived
RT   brain tumor-initiating cells and their parent tumors.";
RL   Neuro-oncol. 18:350-360(2016).
//
RX   PubMed=27006494; DOI=10.1158/1078-0432.CCR-15-1798;
RA   Lun X.-Q., Wells J.C., Grinshtein N., King J.C., Hao X.-G., Dang N.-H.,
RA   Wang X.-L., Aman A., Uehling D., Datti A., Wrana J.L., Easaw J.C.,
RA   Luchman H.A., Weiss S., Cairncross J.G., Kaplan D.R., Robbins S.M.,
RA   Senger D.L.;
RT   "Disulfiram when combined with copper enhances the therapeutic effects
RT   of temozolomide for the treatment of glioblastoma.";
RL   Clin. Cancer Res. 22:3860-3875(2016).
//