ID   BT089
AC   CVCL_UK40
SY   BT89; BT-89
DR   ATCC; CRL-3411
DR   Wikidata; Q93432813
RX   PubMed=26095605;
RX   PubMed=27006494;
RX   PubMed=30153289;
CC   Group: Cancer stem cell line.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=26095605).
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   60Y
CA   Cancer cell line
DT   Created: 25-02-19; Last updated: 29-06-23; Version: 7
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RX   PubMed=26095605; DOI=10.1016/j.stemcr.2015.05.010;
RA   Cusulin C., Chesnelong C., Bose P., Bilenky M., Kopciuk K., Chan J.A.W.,
RA   Cairncross J.G., Jones S.J.M., Marra M.A., Luchman H.A., Weiss S.;
RT   "Precursor states of brain tumor initiating cell lines are predictive
RT   of survival in xenografts and associated with glioblastoma
RT   subtypes.";
RL   Stem Cell Reports 5:1-9(2015).
//
RX   PubMed=27006494; DOI=10.1158/1078-0432.CCR-15-1798;
RA   Lun X.-Q., Wells J.C., Grinshtein N., King J.C., Hao X.-G., Dang N.-H.,
RA   Wang X.-L., Aman A., Uehling D., Datti A., Wrana J.L., Easaw J.C.,
RA   Luchman H.A., Weiss S., Cairncross J.G., Kaplan D.R., Robbins S.M.,
RA   Senger D.L.;
RT   "Disulfiram when combined with copper enhances the therapeutic effects
RT   of temozolomide for the treatment of glioblastoma.";
RL   Clin. Cancer Res. 22:3860-3875(2016).
//
RX   PubMed=30153289; DOI=10.1371/journal.pone.0202860;
RA   Yuan A.L., Ricks C.B., Bohm A.K., Lun X.-Q., Maxwell L., Safdar S.,
RA   Bukhari S., Gerber A., Sayeed W., Bering E.A., Pedersen H.,
RA   Chan J.A.W., Shen Y.-Q., Marra M., Kaplan D.R., Mason W., Goodman L.D.,
RA   Ezhilarasan R., Kaufmann A.B., Cabral M., Robbins S.M., Senger D.L.,
RA   Cahill D.P., Sulman E.P., Cairncross J.G., Blough M.D.;
RT   "ABT-888 restores sensitivity in temozolomide resistant glioma cells
RT   and xenografts.";
RL   PLoS ONE 13:E0202860-E0202860(2018).
//