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Cellosaurus HPB/VP-16 (CVCL_UJ10)

[Text version]
Cell line name HPB/VP-16
Accession CVCL_UJ10
Resource Identification Initiative To cite this cell line use: HPB/VP-16 (RRID:CVCL_UJ10)
Comments Problematic cell line: Contaminated. Parent cell line (HPB-MLT) has been shown to be a HPB-ALL derivative.
Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:4911; Etoposide (VP-16).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; 1539; CBFB + HGNC; 29824; MYL11; Name(s)=CBFB-MYL11, CBFB-MYLPF (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1574Pro (c.4721T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Asp2442fs*39 (c.7326_7326insGGGCCGTGGACG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Cys124Ter (c.372C>A); ClinVar=VCV000458537; Zygosity=Homozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7959 (HPB-MLT)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
Publications

PubMed=1370437; DOI=10.1002/ijc.2910500223
Treichel R.S., Olken S.
The relationship between multi-drug resistance and resistance to natural-killer-cell and lymphokine-activated killer-cell lysis in human leukemic cell lines.
Int. J. Cancer 50:305-310(1992)

PubMed=8099376; DOI=10.1016/0145-2126(93)90124-4
Treichel R.S.
Autologous bone marrow transplantation for leukemia: monoclonal antibody-mediated purging of multidrug-resistant leukemia.
Leuk. Res. 17:491-499(1993)

Cross-references
Cell line databases/resources cancercelllines; CVCL_UJ10
Encyclopedic resources Wikidata; Q94216712
Entry history
Entry creation25-Feb-2019
Last entry update05-Oct-2023
Version number12