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Cellosaurus N6/ADR (CVCL_UJ06)

[Text version]
Cell line name N6/ADR
Synonyms N6/ADR clone B5
Accession CVCL_UJ06
Resource Identification Initiative To cite this cell line use: N6/ADR (RRID:CVCL_UJ06)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 50800; DUX4 + HGNC; 5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
  • Mutation; HGNC; 3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0092 (NALM-6)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3274

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81811
D7S8208,11
D13S3179,11
D16S53910,11
TH018,9
TPOX8,10
vWA15,16

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Publications

PubMed=1370437; DOI=10.1002/ijc.2910500223
Treichel R.S., Olken S.
The relationship between multi-drug resistance and resistance to natural-killer-cell and lymphokine-activated killer-cell lysis in human leukemic cell lines.
Int. J. Cancer 50:305-310(1992)

PubMed=8099376; DOI=10.1016/0145-2126(93)90124-4
Treichel R.S.
Autologous bone marrow transplantation for leukemia: monoclonal antibody-mediated purging of multidrug-resistant leukemia.
Leuk. Res. 17:491-499(1993)

Cross-references
Cell line collections (Providers) ATCC; CRL-3274
Cell line databases/resources cancercelllines; CVCL_UJ06
Encyclopedic resources Wikidata; Q95991928
Entry history
Entry creation25-Feb-2019
Last entry update02-May-2024
Version number12