Cellosaurus cell line hTERT NF1 sipnNF95.12B (CVCL

Cellosaurus hTERT NF1 sipnNF95.12B (CVCL_UI75)

Cross-references
Cell line name	hTERT NF1 sipnNF95.12B
Synonyms	sipnNF95.12B
Accession	CVCL_UI75
Resource Identification Initiative	To cite this cell line use: hTERT NF1 sipnNF95.12B (RRID:CVCL_UI75)
Comments	Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT. Genetic integration: Method=Transduction; Gene=MGI; MGI:88357; Cdk4. Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR). Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Omics: SNP array analysis. Omics: Transcriptome analysis by RNAseq. Derived from site: In situ; Peripheral nervous system, nerve; UBERON=UBERON_0001021. Cell type: Schwann cell; CL=CL_0002573.
Sequence variations	Mutation; HGNC; HGNC:7765; NF1; Simple; p.Leu216Pro (c.647T>C); ClinVar=VCV000068360; Zygosity=Heterozygous; Note=Germline (PubMed=27617404).
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Female
Category	Telomerase immortalized cell line
Publications	PubMed=27617404; DOI=10.1038/labinvest.2016.88 Li H., Chang L.-J., Neubauer D.R., Muir D.F. 4th, Wallace M.R. Immortalization of human normal and NF1 neurofibroma Schwann cells. Lab. Invest. 96:1105-1115(2016) PubMed=29893754; DOI=10.1038/sdata.2018.106; PMCID=PMC5996849 Ferrer M., Gosline S.J.C., Stathis M., Zhang X.-H., Guo X.-D., Guha R., Ryman D.A., Wallace M.R., Kasch-Semenza L., Hao H.-P., Ingersoll R.G., Mohr D., Thomas C.J., Verma S., Guinney J.H., Blakeley J.O. Pharmacological and genomic profiling of neurofibromatosis type 1 plexiform neurofibroma-derived Schwann cells. Sci. Data 5:180106-180106(2018)
Encyclopedic resources	Wikidata; Q94305862
Entry history
Entry creation	25-Feb-2019
Last entry update	19-Dec-2024
Version number	11