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Cellosaurus hTERT NF1 ipNF06.2A (CVCL_UI74)

[Text version]
Cell line name hTERT NF1 ipNF06.2A
Synonyms ipNF06.2A
Accession CVCL_UI74
Resource Identification Initiative To cite this cell line use: hTERT NF1 ipNF06.2A (RRID:CVCL_UI74)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=MGI; MGI:88357; Cdk4.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Peripheral nervous system, nerve; UBERON=UBERON_0001021.
Cell type: Schwann cell; CL=CL_0002573.
Sequence variations
  • Mutation; HGNC; HGNC:7765; NF1; Simple; p.Gly848Trp (c.2542G>T); Zygosity=Heterozygous; Note=Germline (PubMed=27617404).
Disease Neurofibromatosis type 1 (NCIt: C3273)
Neurofibromatosis type 1 (ORDO: Orphanet_636)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 60-70Y
Category Telomerase immortalized cell line
Publications

PubMed=27617404; DOI=10.1038/labinvest.2016.88
Li H., Chang L.-J., Neubauer D.R., Muir D.F. 4th, Wallace M.R.
Immortalization of human normal and NF1 neurofibroma Schwann cells.
Lab. Invest. 96:1105-1115(2016)

PubMed=29893754; DOI=10.1038/sdata.2018.106; PMCID=PMC5996849
Ferrer M., Gosline S.J.C., Stathis M., Zhang X.-H., Guo X.-D., Guha R., Ryman D.A., Wallace M.R., Kasch-Semenza L., Hao H.-P., Ingersoll R.G., Mohr D., Thomas C.J., Verma S., Guinney J.H., Blakeley J.O.
Pharmacological and genomic profiling of neurofibromatosis type 1 plexiform neurofibroma-derived Schwann cells.
Sci. Data 5:180106-180106(2018)

Cross-references
Cell line collections (Providers) ABM; T0191
Encyclopedic resources Wikidata; Q94305834
Entry history
Entry creation25-Feb-2019
Last entry update19-Dec-2024
Version number10