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Cellosaurus hTERT NF1 ipNF95.11b C (CVCL_UI67)

[Text version]
Cell line name hTERT NF1 ipNF95.11b C
Synonyms ipNF95.11b C; ipNF95.11b "C"; ipNF95.11bC
Accession CVCL_UI67
Resource Identification Initiative To cite this cell line use: hTERT NF1 ipNF95.11b C (RRID:CVCL_UI67)
Comments Doubling time: ~32.7 hours (ATCC=CRL-3390).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=MGI; MGI:88357; Cdk4.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Peripheral nervous system, nerve; UBERON=UBERON_0001021.
Cell type: Schwann cell; CL=CL_0002573.
Sequence variations
  • Gene deletion; HGNC; HGNC:7765; NF1; Zygosity=Heterozygous; Note=Somatic LOH (PubMed=27617404).
  • Mutation; HGNC; HGNC:7765; NF1; Simple; p.Thr586Valfs*18 (c.1756_1759delACTA) (1756delACTA); ClinVar=VCV000186215; Zygosity=Heterozygous; Note=Germline (PubMed=27617404).
Disease Neurofibromatosis type 1 (NCIt: C3273)
Neurofibromatosis type 1 (ORDO: Orphanet_636)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_UI68 ! hTERT NF1 ipNF95.11b C/T
CVCL_UI69 ! hTERT NF1 ipnNF95.11c
Sex of cell Male
Age at sampling 19Y
Category Telomerase immortalized cell line
STR profile Source(s): ATCC=CRL-3390; PubMed=27617404

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133823,24
D3S135817
D5S81811
D7S82010,12
D8S117910,14
D13S31711
D16S53913,14
D18S5112,15
D19S43313,14
D21S1129,31.2
FGA22,23
Penta D8,11
Penta E7,13
TH018,9
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Web pages http://www.n-tap.org/plexiform-neurofibromas/cell-lines/
Publications

PubMed=27617404; DOI=10.1038/labinvest.2016.88
Li H., Chang L.-J., Neubauer D.R., Muir D.F. 4th, Wallace M.R.
Immortalization of human normal and NF1 neurofibroma Schwann cells.
Lab. Invest. 96:1105-1115(2016)

PubMed=29055717; DOI=10.1016/j.expneurol.2017.10.012; PMCID=PMC6863155
Kraniak J.M., Chalasani A., Wallace M.R., Mattingly R.R.
Development of 3D culture models of plexiform neurofibroma and initial application for phenotypic characterization and drug screening.
Exp. Neurol. 299:289-298(2018)

PubMed=29893754; DOI=10.1038/sdata.2018.106; PMCID=PMC5996849
Ferrer M., Gosline S.J.C., Stathis M., Zhang X.-H., Guo X.-D., Guha R., Ryman D.A., Wallace M.R., Kasch-Semenza L., Hao H.-P., Ingersoll R.G., Mohr D., Thomas C.J., Verma S., Guinney J.H., Blakeley J.O.
Pharmacological and genomic profiling of neurofibromatosis type 1 plexiform neurofibroma-derived Schwann cells.
Sci. Data 5:180106-180106(2018)

Cross-references
Cell line collections (Providers) ABM; T0179
ATCC; CRL-3390
Encyclopedic resources Wikidata; Q94305840
Entry history
Entry creation25-Feb-2019
Last entry update19-Dec-2024
Version number12