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Cellosaurus CV-hIPS-B-APP-KO clone 1B6 (CVCL_UI22)

[Text version]
Cell line name CV-hIPS-B-APP-KO clone 1B6
Synonyms GM25430-APP-KO clone 1B6; 1B6; APPnull in CV background
Accession CVCL_UI22
Resource Identification Initiative To cite this cell line use: CV-hIPS-B-APP-KO clone 1B6 (RRID:CVCL_UI22)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:620; APP.
Derived from site: In situ; Arm, skin; UBERON=UBERON_0002427.
Cell type: Fibroblast of skin; CL=CL_0002620.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1N86 (CV-hIPS-B)
Sex of cell Male
Age at sampling 62Y
Category Induced pluripotent stem cell
Publications

PubMed=30686764; DOI=10.1016/j.stem.2018.12.013; PMCID=PMC6414424
van der Kant R., Langness V.F., Herrera C.M., Williams D.A., Fong L.K., Leestemaker Y., Steenvoorden E., Rynearson K.D., Brouwers J.F., Helms J.B., Ovaa H., Giera M., Wagner S.L., Bang A.G., Goldstein L.S.B.
Cholesterol metabolism is a druggable axis that independently regulates Tau and amyloid-beta in iPSC-derived Alzheimer's disease neurons.
Cell Stem Cell 24:363-375.e9(2019)

Cross-references
Encyclopedic resources Wikidata; Q93460586
Entry history
Entry creation25-Feb-2019
Last entry update19-Dec-2024
Version number8