Cellosaurus HEK-Blue IL-18 (CVCL_UF33)
| Cell line name | HEK-Blue IL-18 |
|---|---|
| Accession | CVCL_UF33 |
| Resource Identification Initiative | To cite this cell line use: HEK-Blue IL-18 (RRID:CVCL_UF33) |
| Comments | Characteristics: Designed to detect bioactive human IL18 (and to a lesser extent mouse IL18) by monitoring the activation of the NF-kappaB and AP-1 pathways. In addition, the TNF-alpha and the IL-1beta responses have been blocked (InvivoGen). Characteristics: SEAP (secreted ALPP) reporter cell line, in this cell line SEAP is under the control of a promoter with NF-kappaB and AP-1-binding sites. Knockout cell: Method=Not specified; HGNC; HGNC:5993; IL1R1. Knockout cell: Method=Not specified; HGNC; HGNC:5995; IL1RAP. Knockout cell: Method=Not specified; HGNC; HGNC:11916; TNFRSF1A. Knockout cell: Method=Not specified; HGNC; HGNC:11917; TNFRSF1B. Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:439; ALPP. Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5988; IL18R1. Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5989; IL18RAP. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P33967; B.cereus Bsr. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR). Transformant: NCBI_TaxID; 28285; Adenovirus 5. Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113. |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy | Parent: CVCL_0045 (HEK293) |
| Sex of cell | Female |
| Age at sampling | Fetus |
| Category | Transformed cell line |
| Web pages | https://www.invivogen.com/hek-blue-il18 |
| Cross-references | |
| Encyclopedic resources | Wikidata; Q94092308 |
| Entry history | |
| Entry creation | 13-Nov-2018 |
| Last entry update | 19-Dec-2024 |
| Version number | 10 |