ID   DIF3-17
AC   CVCL_UF12
DR   cancercelllines; CVCL_UF12
DR   Wikidata; Q93527510
RX   PubMed=3785169;
CC   Population: African; Kenyan.
CC   Characteristics: Strongly resistant to both the antiviral and antiproliferative actions of interferons.
CC   Sequence variation: Gene fusion; HGNC; 5477; IGH + HGNC; 7553; MYC; Name(s)=MYC-IGH (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 914; B2M; Simple; p.Met1Ile (c.3G>C); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ala5_Ala80del (c.14_241del228); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_UF11 ! DIF3
SX   Male
AG   16Y
CA   Cancer cell line
DT   Created: 13-11-18; Last updated: 05-10-23; Version: 11
//
RX   PubMed=3785169; DOI=10.1128/mcb.6.5.1374-1378.1986; PMCID=PMC367660;
RA   Dron M., Modjtahedi N., Brison O., Tovey M.G.;
RT   "Interferon modulation of c-myc expression in cloned Daudi cells:
RT   relationship to the phenotype of interferon resistance.";
RL   Mol. Cell. Biol. 6:1374-1378(1986).
//