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Cellosaurus NCI-H1975 EGFR T790M/C797S/L858R (CVCL_UE30)

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Cell line name NCI-H1975 EGFR T790M/C797S/L858R
Synonyms NCI-H1975 L858R/T790M/C797S
Accession CVCL_UE30
Resource Identification Initiative To cite this cell line use: NCI-H1975 EGFR T790M/C797S/L858R (RRID:CVCL_UE30)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3236; EGFR; Simple_edited; p.Cys797Ser (c.2389T>A); ClinVar=VCV000376342; Zygosity=Unspecified; Note=By CRISPR/Cas9 (KYinno=KC-0128).
  • Mutation; HGNC; 3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Gly118Asp (c.353G>A); ClinVar=VCV000156446; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1511 (NCI-H1975)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Cross-references
Cell line collections (Providers) KYinno; KC-0128
Cell line databases/resources cancercelllines; CVCL_UE30
Encyclopedic resources Wikidata; Q95993283
Entry history
Entry creation13-Nov-2018
Last entry update10-Sep-2024
Version number12