Cellosaurus cell line UP-ALL13 (CVCL

Cellosaurus UP-ALL13 (CVCL_UD75)

[Text version]

Cell line name

UP-ALL13

Synonyms

University of Padua-T-cell Acute Lymphoblastic Leukemia 13

Accession

CVCL_UD75

Resource Identification Initiative

To cite this cell line use: UP-ALL13 (RRID:CVCL_UD75)

Comments

Doubling time: 60-72 hours (PubMed=30304769).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: H3K27ac ChIP-seq epigenome analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.

Sequence variations

Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=30304769).
Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=30304769).
Gene deletion; HGNC; HGNC:9588; PTEN; Zygosity=Heterozygous (PubMed=30304769).
Mutation; HGNC; HGNC:2978; DNMT3A; Simple; p.Arg882His (c.2645G>A); ClinVar=VCV000375881; Zygosity=Heterozygous (PubMed=30304769).

Disease

Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

Category

Cancer cell line

STR profile

Source(s): PubMed=30304769

Markers:

Amelogenin	X,Y
CSF1PO	11,13
D3S1358	14
D5S818	12,13
D7S820	9,13
D8S1179	14,15
D13S317	8,12
D16S539	12
D18S51	14,15
D21S11	29,30
FGA	23,24
Penta D	9,14
Penta E	5,12
TH01	9.3
TPOX	8
vWA	18,20

Publications

PubMed=30304769; DOI=10.3390/cells7100160; PMCID=PMC6209910
Tosello V., Milani G., Martines A., Macri N., Van Loocke W., Matthijssens F., Buldini B., Minuzzo S.A., Bongiovanni D., Schumacher R.F., Amadori A., Van Vlierberghe P., Piovan E.
A novel t(8;14)(q24;q11) rearranged human cell line as a model for mechanistic and drug discovery studies of NOTCH1-independent human T-cell leukemia.
Cells 7:160.1-160.17(2018)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_UD75

Encyclopedic resources

Wikidata; Q98134337

Entry history

Entry creation

13-Nov-2018

Last entry update

19-Dec-2024

Version number