Cellosaurus WC024i-FXS-Nluc1 (CVCL_UA51)
| Cell line name | WC024i-FXS-Nluc1 |
|---|---|
| Synonyms | FX-iPSC-Nluc1 |
| Accession | CVCL_UA51 |
| Resource Identification Initiative | To cite this cell line use: WC024i-FXS-Nluc1 (RRID:CVCL_UA51) |
| Comments | Characteristics: CRISPR/Cas9-mediated knock-in of a P2A-NanoLuc construct at the C-terminal end of FMR1. Characteristics: Reporter cell line to detect FMR1 gene reactivation in human neural cells and can be a valuable resource to identify novel compounds for FMR1 gene reactivation studies (WiCell=wc024i-fxs-nluc1). Genetic integration: Method=Transfection/transduction; Gene=NanoLuc (Note=19 kDa ATP-independent bright luminescent protein derived from O.gracilirostris). Derived from site: In situ; Skin; UBERON=UBERON_0002097. Cell type: Fibroblast of skin; CL=CL_0002620. |
| Sequence variations |
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| Disease | Fragile X syndrome (NCIt: C84717) Fragile X syndrome (ORDO: Orphanet_908) |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy | Parent: CVCL_EJ78 (WC007i-FX13-2) |
| Sex of cell | Male |
| Age at sampling | 8Y |
| Category | Induced pluripotent stem cell |
| Publications | PubMed=27422057; DOI=10.1002/stem.2463; PMCID=PMC5195860 |
| Cross-references | |
| Cell line collections (Providers) | WiCell; wc024i-fxs-nluc1 |
| Encyclopedic resources | Wikidata; Q98134811 |
| Entry history | |
| Entry creation | 13-Nov-2018 |
| Last entry update | 10-Sep-2024 |
| Version number | 12 |