ID   ORS [Human Ewing sarcoma]
AC   CVCL_U565
DR   cancercelllines; CVCL_U565
DR   Cosmic; 2250465
DR   Wikidata; Q54936518
RX   DOI=10.5282/edoc.27750;
RX   PubMed=11423975;
RX   PubMed=25223734;
CC   From: Delattre, Olivier; Institut Curie; Paris; France.
CC   Sequence variation: Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 4 fusion (Ex10/Ex5) (PubMed=11423975).
CC   Sequence variation: Mutation; HGNC; HGNC:11355; STAG2; Simple; p.Asp625fs; Zygosity=Unspecified (PubMed=25223734).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys176Phe (c.527G>T); ClinVar=VCV000376569; Zygosity=Unspecified (PubMed=25223734).
DI   NCIt; C4817; Ewing sarcoma
DI   ORDO; Orphanet_319; Ewing sarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 16-04-14; Last updated: 19-12-24; Version: 17
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RX   DOI=10.5282/edoc.27750;
RA   Orth M.F.;
RT   "Systematic multi-omics profiling of Ewing sarcoma cell lines.";
RL   Thesis PhD (2021); Ludwig Maximilians University of Munich; Munich; Germany.
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RX   PubMed=11423975; DOI=10.1038/sj.onc.1204437;
RA   Dauphinot L., De Oliveira C., Melot T., Sevenet N., Thomas V.,
RA   Weissman B.E., Delattre O.;
RT   "Analysis of the expression of cell cycle regulators in Ewing cell
RT   lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression.";
RL   Oncogene 20:3258-3265(2001).
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RX   PubMed=25223734; DOI=10.1158/2159-8290.CD-14-0622; PMCID=PMC4264969;
RA   Tirode F., Surdez D., Ma X.-T., Parker M., Le Deley M.-C., Bahrami A.,
RA   Zhang Z.-J., Lapouble E., Grossetete-Lalami S., Rusch M., Reynaud S.,
RA   Rio-Frio T., Hedlund E., Wu G., Chen X., Pierron G., Oberlin O.,
RA   Zaidi S., Lemmon G., Gupta P., Vadodaria B., Easton J., Gut M.,
RA   Ding L., Mardis E.R., Wilson R.K., Shurtleff S., Laurence V.,
RA   Michon J., Marec-Berard P., Gut I.G., Downing J.R., Dyer M.A.,
RA   Zhang J.-H., Delattre O.;
RG   International Cancer Genome Consortium;
RG   St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project;
RT   "Genomic landscape of Ewing sarcoma defines an aggressive subtype with
RT   co-association of STAG2 and TP53 mutations.";
RL   Cancer Discov. 4:1342-1353(2014).
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