ID   AG11395
AC   CVCL_U281
SY   WS780
DR   CLO; CLO_0021582
DR   EFO; EFO_0022407
DR   Coriell; AG11395
DR   GEO; GSM1052419
DR   Wikidata; Q54743912
RX   CelloPub=CLPUB00597;
RX   CelloPub=CLPUB00712;
RX   PubMed=1671011;
RX   PubMed=9230208;
RX   PubMed=10606667;
RX   PubMed=19935656;
RX   PubMed=23257959;
CC   Characteristics: Cell line positive for alternative lengthening of telomeres (ALT+) (CelloPub=CLPUB00712; PubMed=19935656).
CC   Sequence variation: Mutation; HGNC; 12791; WRN; Simple; p.Arg369Ter (c.1105C>T) (c.1336C>T); ClinVar=VCV000005449; Zygosity=Homozygous (PubMed=9230208; Coriell=AG11395).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Omics: DNA methylation analysis.
CC   Misspelling: AG11385; GEO=GSM1052419; PubMed=23257959.
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
DI   NCIt; C3447; Werner syndrome
DI   ORDO; Orphanet_902; Werner syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_U282 ! AG00780
SX   Male
AG   60Y
CA   Transformed cell line
DT   Created: 03-02-14; Last updated: 10-09-24; Version: 21
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RX   CelloPub=CLPUB00597;
RG   National Institute on Aging;
RT   "1994 catalog of cell lines. NIA Aging Cell Repository.";
RL   (In misc. document) Institute for Medical Research (Camden, N.J.); pp.1-351; National Institutes of Health; Bethesda; USA (1994).
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RX   CelloPub=CLPUB00712;
RA   Henson J.D.;
RT   "The role of alternative lengthening of telomeres in human cancer.";
RL   Thesis PhD (2006); University of Sydney; Sydney; Australia.
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RX   PubMed=1671011; DOI=10.1016/0014-4827(91)90054-X;
RA   Saito H., Moses R.E.;
RT   "Immortalization of Werner syndrome and progeria fibroblasts.";
RL   Exp. Cell Res. 192:373-379(1991).
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RX   PubMed=9230208;
RA   Bennett S.E., Umar A., Oshima J., Monnat R.J. Jr., Kunkel T.A.;
RT   "Mismatch repair in extracts of Werner syndrome cell lines.";
RL   Cancer Res. 57:2956-2960(1997).
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RX   PubMed=10606667; DOI=10.1093/nar/28.2.648; PMCID=PMC102521;
RA   Moser M.J., Kamath-Loeb A.S., Jacob J.E., Bennett S.E., Oshima J.,
RA   Monnat R.J. Jr.;
RT   "WRN helicase expression in Werner syndrome cell lines.";
RL   Nucleic Acids Res. 28:648-654(2000).
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RX   PubMed=19935656; DOI=10.1038/nbt.1587;
RA   Henson J.D., Cao Y., Huschtscha L.I., Chang A.C.-M., Au A.Y.M.,
RA   Pickett H.A., Reddel R.R.;
RT   "DNA C-circles are specific and quantifiable markers of
RT   alternative-lengthening-of-telomeres activity.";
RL   Nat. Biotechnol. 27:1181-1185(2009).
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RX   PubMed=23257959; DOI=10.4161/epi.23366; PMCID=PMC3549877;
RA   Heyn H., Moran S., Esteller M.;
RT   "Aberrant DNA methylation profiles in the premature aging disorders
RT   Hutchinson-Gilford progeria and Werner syndrome.";
RL   Epigenetics 8:28-33(2013).
//