Cell line name |
CEM/A7 |
Synonyms |
CEM-A7 |
Accession |
CVCL_U261 |
Resource Identification Initiative |
To cite this cell line use: CEM/A7 (RRID:CVCL_U261) |
Comments |
Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. |
Sequence variations |
- Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0207 (CCRF-CEM) |
Sex of cell |
Female |
Age at sampling |
3Y11M |
Category |
Cancer cell line |
Publications | PubMed=7903222; DOI=10.1007/BF00685329 Zalcberg J.R., Hu X.F., Ching M., Wakeling A.E., Wall D.M., Marschner I.C., de Luise M. Differential effects of estrogen, tamoxifen and the pure antiestrogen ICI 182,780 in human drug-resistant leukemia cell lines. Cancer Chemother. Pharmacol. 33:123-129(1993) PubMed=7514153; DOI=10.1002/ijc.2910570414 Zalcberg J.R., Hu X.F., Wall D.M., Mirski S.E.L., Cole S.P.C., Nadalin G., de Luise M., Parkin J.D., Vrazas V., Campbell L.J., Kantharidis P. Cellular and karyotypic characterization of two doxorubicin resistant cell lines isolated from the same parental human leukemia cell line. Int. J. Cancer 57:522-528(1994) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_U261
|
Encyclopedic resources |
Wikidata; Q54809267
|
Entry history |
Entry creation | 03-Feb-2014 |
Last entry update | 19-Dec-2024 |
Version number | 20 |
---|