Cellosaurus HeLa/Fucci2 (CVCL_U187)
| Cell line name | HeLa/Fucci2 |
|---|---|
| Synonyms | HeLa/Fucci2 #3; HeLa.S-Fucci2; HeLa/Fucci(SA)2 |
| Accession | CVCL_U187 |
| Resource Identification Initiative | To cite this cell line use: HeLa/Fucci2 (RRID:CVCL_U187) |
| Comments | Population: African American. Characteristics: Used for study of cell cycle progression thanks to the inclusion of a Fucci2 (Fluorescent Ubiquitination-based Cell Cycle Indicator 2) construct. Characteristics: Transfected with the Fucci2 probe which consist of the fusion of mCherry) to the ubiquitination domain of human CDT1 (AA 30-120) and of monomeric Venus (mVenus) to the ubiquitination domain of human geminin (AA 1-110). Genetic integration: Method=Transfection; Gene=HGNC; HGNC:24576; CDT1 (Note=With p.Met1_Thr29del and p.Ser121_Leu546del). Genetic integration: Method=Transfection; Gene=HGNC; HGNC:17493; GMNN (Note=With p.Tyr111_Ile209del). Genetic integration: Method=Transfection; Gene=FPbase; ZERB6; mCherry (Note=Red fluorescent protein derived from drFP583 (dsRed)). Genetic integration: Method=Transfection; Gene=FPbase; YUJWJ; Venus (Note=Bright yellow fluorescent protein derived from GFP). Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18). Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002. |
| Disease | Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677) |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy | Parent: CVCL_0030 (HeLa) |
| Sex of cell | Female |
| Age at sampling | 30Y6M |
| Category | Cancer cell line |
| Publications | PubMed=21226962; DOI=10.1186/1471-2121-12-2; PMCID=PMC3277280 PubMed=29107535; DOI=10.1016/j.molcel.2017.10.001 |
| Cross-references | |
| Cell line collections (Providers) | RCB; RCB2867 |
| Cell line databases/resources | CLO; CLO_0050932 |
| Chemistry resources | ChEMBL-Cells; CHEMBL4630774
ChEMBL-Targets; CHEMBL4630782 PubChem_Cell_line; CVCL_U187 |
| Encyclopedic resources | Wikidata; Q54882692 |
| Entry history | |
| Entry creation | 03-Feb-2014 |
| Last entry update | 19-Dec-2024 |
| Version number | 16 |