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Cellosaurus NB4-S1 (CVCL_U086)

[Text version]
Cell line name NB4-S1
Accession CVCL_U086
Resource Identification Initiative To cite this cell line use: NB4-S1 (RRID:CVCL_U086)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_15367; All-trans-retinoic acid (ATRA; Tretinoin).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:9113; PML + HGNC; HGNC:9864; RARA; Name(s)=PML-RARA (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Acute promyelocytic leukemia with PML-RARA (NCIt: C3182)
Acute promyelocytic leukemia (ORDO: Orphanet_520)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0005 (NB4)
Children:
CVCL_U087 (NB4-DR2)CVCL_U088 (NB4-DR3)
Sex of cell Female
Age at sampling 23Y
Category Cancer cell line
Publications

PubMed=9342843; DOI=10.1046/j.1432-0436.1997.6150321.x
Nason-Burchenal K., Maerz W., Albanell J., Allopenna J.J., Martin P., Moore M.A.S., Dmitrovsky E.
Common defects of different retinoic acid resistant promyelocytic leukemia cells are persistent telomerase activity and nuclear body disorganization.
Differentiation 61:321-331(1997)

PubMed=9716606; DOI=10.1182/blood.V92.5.1758
Nason-Burchenal K., Allopenna J.J., Begue A., Stehelin D., Dmitrovsky E., Martin P.
Targeting of PML/RARalpha is lethal to retinoic acid-resistant promyelocytic leukemia cells.
Blood 92:1758-1767(1998)

Cross-references
Cell line databases/resources cancercelllines; CVCL_U086
TOKU-E; 4157
Encyclopedic resources Wikidata; Q54907534
Entry history
Entry creation03-Feb-2014
Last entry update19-Dec-2024
Version number20