Cell line name |
NB4-DR1 |
Synonyms |
NB4-R1 |
Accession |
CVCL_U085 |
Resource Identification Initiative |
To cite this cell line use: NB4-DR1 (RRID:CVCL_U085) |
Comments |
Population: Caucasian. Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371. |
Sequence variations |
- Gene fusion; HGNC; HGNC:9113; PML + HGNC; HGNC:9864; RARA; Name(s)=PML-RARA (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
|
Disease |
Acute promyelocytic leukemia with PML-RARA (NCIt: C3182) Acute promyelocytic leukemia (ORDO: Orphanet_520) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0005 (NB4) |
Sex of cell |
Female |
Age at sampling |
23Y |
Category |
Cancer cell line |
Publications | PubMed=9342843; DOI=10.1046/j.1432-0436.1997.6150321.x Nason-Burchenal K., Maerz W., Albanell J., Allopenna J.J., Martin P., Moore M.A.S., Dmitrovsky E. Common defects of different retinoic acid resistant promyelocytic leukemia cells are persistent telomerase activity and nuclear body disorganization. Differentiation 61:321-331(1997) PubMed=9716606; DOI=10.1182/blood.V92.5.1758 Nason-Burchenal K., Allopenna J.J., Begue A., Stehelin D., Dmitrovsky E., Martin P. Targeting of PML/RARalpha is lethal to retinoic acid-resistant promyelocytic leukemia cells. Blood 92:1758-1767(1998) PubMed=11704857; DOI=10.1038/sj.onc.1204863 Roussel M.J.S., Lanotte M. Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes. Oncogene 20:7287-7291(2001) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_U085
|
Encyclopedic resources |
Wikidata; Q54907529
|
Entry history |
Entry creation | 03-Feb-2014 |
Last entry update | 19-Dec-2024 |
Version number | 18 |
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