Cell line name |
NB4.007/6 |
Synonyms |
NB4-007/6; NB4-GR007/6 |
Accession |
CVCL_U083 |
Resource Identification Initiative |
To cite this cell line use: NB4.007/6 (RRID:CVCL_U083) |
Comments |
Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_15367; All-trans-retinoic acid (ATRA; Tretinoin). Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371. |
Sequence variations |
- Gene fusion; HGNC; HGNC:9113; PML + HGNC; HGNC:9864; RARA; Name(s)=PML-RARA (PubMed=12353268).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
|
Disease |
Acute promyelocytic leukemia with PML-RARA (NCIt: C3182) Acute promyelocytic leukemia (ORDO: Orphanet_520) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0005 (NB4) |
Sex of cell |
Female |
Age at sampling |
23Y |
Category |
Cancer cell line |
Publications | PubMed=7719237; DOI=10.3109/10428199509049768 Dermime S., Grignani F., Rogaia D., Liberatore C., Marchesi E., Gambacorti-Passerini C. Acute promyelocytic leukaemia cells resistant to retinoic acid show further perturbation of the RAR alpha signal transduction system. Leuk. Lymphoma 16:289-295(1995) PubMed=11704857; DOI=10.1038/sj.onc.1204863 Roussel M.J.S., Lanotte M. Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes. Oncogene 20:7287-7291(2001) PubMed=12353268; DOI=10.1002/gcc.10117 Mozziconacci M.-J., Rosenauer A., Restouin A., Fanelli M., Shao W.-L., Fernandez F., Toiron Y., Viscardi J., Gambacorti-Passerini C., Miller W.H. Jr., Lafage-Pochitaloff M. Molecular cytogenetics of the acute promyelocytic leukemia-derived cell line NB4 and of four all-trans retinoic acid-resistant subclones. Genes Chromosomes Cancer 35:261-270(2002) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_U083
|
Encyclopedic resources |
Wikidata; Q54907536
|
Entry history |
Entry creation | 03-Feb-2014 |
Last entry update | 19-Dec-2024 |
Version number | 18 |
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