• Gene fusion; HGNC; HGNC:9113; PML + HGNC; HGNC:9864; RARA; Name(s)=PML-RARA (from parent cell line).
  
• Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
  
• Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
  

PubMed=7915840; DOI=10.1073/pnas.91.18.8428; PMCID=PMC44619
Ruchaud S., Duprez E., Gendron M.-C., Houge G., Genieser H.-G., Jastorff B., Doskeland S.O., Lanotte M.
Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cell line.
Proc. Natl. Acad. Sci. U.S.A. 91:8428-8432(1994)

PubMed=10673742; DOI=10.1038/sj.leu.2401683
Duprez E., Benoit G., Flexor M., Lillehaug J.R., Lanotte M.
A mutated PML/RARA found in the retinoid maturation resistant NB4 subclone, NB4-R2, blocks RARA and wild-type PML/RARA transcriptional activities.
Leukemia 14:255-261(2000)

PubMed=11704857; DOI=10.1038/sj.onc.1204863
Roussel M.J.S., Lanotte M.
Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes.
Oncogene 20:7287-7291(2001)