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Cellosaurus HAP1 SIK1 (-) 1 (CVCL_TL12)

[Text version]
Cell line name HAP1 SIK1 (-) 1
Synonyms HZGHC000063c012; SIK1 knockout cell line 1bp insertion in exon 5; HAP1 SIK1 (-)
Accession CVCL_TL12
Resource Identification Initiative To cite this cell line use: HAP1 SIK1 (-) 1 (RRID:CVCL_TL12)
Comments Group: Haploid karyotype cell line.
Knockout cell: Method=CRISPR/Cas9; HGNC; 11142; SIK1.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_Y019 (HAP1)
Children:
CVCL_DX56 (HAP1 SIK1 (-) SIK3 (-) 1)CVCL_DX57 (HAP1 SIK1 (-) SIK3 (-) 2)
Sex of cell Male
Age at sampling 40Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Horizon_Discovery; HZGHC000063c012
Cell line databases/resources cancercelllines; CVCL_TL12
Encyclopedic resources Wikidata; Q54879804
Entry history
Entry creation14-May-2018
Last entry update30-Jan-2024
Version number11