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Cellosaurus HAP1 NLK (-) 1 (CVCL_TA75)

[Text version]
Cell line name HAP1 NLK (-) 1
Synonyms HZGHC000096c005; NLK knockout cell line 8bp insertion
Accession CVCL_TA75
Resource Identification Initiative To cite this cell line use: HAP1 NLK (-) 1 (RRID:CVCL_TA75)
Comments Group: Haploid karyotype cell line.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:29858; NLK.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_Y019 (HAP1)
Sex of cell Male
Age at sampling 40Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Horizon_Discovery; HZGHC000096c005 - Discontinued
Cell line databases/resources cancercelllines; CVCL_TA75
Encyclopedic resources Wikidata; Q54876622
Entry history
Entry creation14-May-2018
Last entry update19-Dec-2024
Version number12