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Cellosaurus PA1 (CVCL_T887)

[Text version]
Cell line name PA1
Accession CVCL_T887
Resource Identification Initiative To cite this cell line use: PA1 (RRID:CVCL_T887)
Comments Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; HGNC:8607; PRKN; Unexplicit; Ex2-4del; Zygosity=Homozygous (PubMed=23039195).
Disease Parkinson disease 2, autosomal recessive juvenile (NCIt: C198603)
Young-onset Parkinson disease (ORDO: Orphanet_2828)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_T885 ! PA9
CVCL_T886 ! PA22
Sex of cell Female
Age at sampling 72Y
Category Induced pluripotent stem cell
Publications

PubMed=23039195; DOI=10.1186/1756-6606-5-35; PMCID=PMC3546866
Imaizumi Y., Okada Y., Akamatsu W., Koike M., Kuzumaki N., Hayakawa H., Nihira T., Kobayashi T., Ohyama M., Sato S., Takanashi M., Funayama M., Hirayama A., Soga T., Hishiki T., Suematsu M., Yagi T., Ito D., Kosakai A., Hayashi K., Shouji M., Nakanishi A., Suzuki N., Mizuno Y., Mizushima N., Amagai M., Uchiyama Y., Mochizuki H., Hattori N., Okano H.
Mitochondrial dysfunction associated with increased oxidative stress and alpha-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue.
Mol. Brain 5:35.1-35.13(2012)

Cross-references
Cell line databases/resources SKIP; SKIP000521
Encyclopedic resources Wikidata; Q54937345
Entry history
Entry creation03-Feb-2014
Last entry update19-Dec-2024
Version number11