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Cellosaurus PC-9/BR (CVCL_T015)

[Text version]
Cell line name PC-9/BR
Synonyms PC-9BR; PC-9/BRc1; PC-9BRc1
Accession CVCL_T015
Resource Identification Initiative To cite this cell line use: PC-9/BR (RRID:CVCL_T015)
Comments Population: Chinese; Han and Japanese.
Selected for resistance to: ChEBI; CHEBI_61390; Afatinib (BIBW-2992).
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=21734175; DOI=10.1126/scitranslmed.3002356; PMCID=PMC3500629
Chmielecki J., Foo J., Oxnard G.R., Hutchinson K., Ohashi K., Somwar R., Wang L., Amato K.R., Arcila M.E., Sos M.L., Socci N.D., Viale A.J., de Stanchina E., Ginsberg M.S., Thomas R.K., Kris M.G., Inoue A., Ladanyi M., Miller V.A., Michor F., Pao W.
Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling.
Sci. Transl. Med. 3:90ra59.1-90ra59.10(2011)

PubMed=23733853; DOI=10.1101/gr.152322.112; PMCID=PMC3759720
Jia P.-L., Jin H.-L., Meador C.B., Xia J.-F., Ohashi K., Liu L., Pirazzoli V., Dahlman K.B., Politi K., Michor F., Zhao Z.-M., Pao W.
Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance.
Genome Res. 23:1434-1445(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_T015
Encyclopedic resources Wikidata; Q54938480
Polymorphism and mutation databases Cosmic; 2015227
Entry history
Entry creation03-Feb-2014
Last entry update19-Dec-2024
Version number20