ID   TCam-2
AC   CVCL_T012
SY   TCAM-2; TCam 2; T-CAM2; TCam2; T-CAM
DR   EFO; EFO_0022718
DR   Cosmic; 1449155
DR   Cosmic; 2077183
DR   Cosmic; 2163764
DR   Cosmic; 2806820
DR   Cosmic; 2807076
DR   GEO; GSM5209339
DR   GEO; GSM5209340
DR   GEO; GSM5209341
DR   GEO; GSM5209342
DR   GEO; GSM5209343
DR   GEO; GSM5209344
DR   GEO; GSM5209345
DR   GEO; GSM5209346
DR   Wikidata; Q54971858
RX   PubMed=8394948;
RX   PubMed=18008088;
RX   PubMed=18050305;
RX   PubMed=20607849;
RX   PubMed=21668453;
RX   PubMed=23374840;
RX   PubMed=24812411;
RX   PubMed=34153645;
RX   PubMed=36899312;
CC   Population: Japanese.
CC   Doubling time: 55.3 hours (Note=At 10th passage) (PubMed=8394948).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Testis; UBERON=UBERON_0000473.
DI   NCIt; C7328; Testicular seminoma
DI   ORDO; Orphanet_842; Testicular seminomatous germ cell tumor
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   35Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 10-09-24; Version: 17
//
RX   PubMed=8394948; DOI=10.5980/jpnjurol1989.84.1211;
RA   Mizuno Y., Gotoh A., Kamidono S., Kitazawa S.;
RT   "Establishment and characterization of a new human testicular germ
RT   cell tumor cell line (TCam-2).";
RL   Nihon Hinyokika Gakkai Zasshi 84:1211-1218(1993).
//
RX   PubMed=18008088; DOI=10.1007/s00441-007-0527-y;
RA   Eckert D., Nettersheim D., Heukamp L.C., Kitazawa S., Biermann K.,
RA   Schorle H.;
RT   "TCam-2 but not JKT-1 cells resemble seminoma in cell culture.";
RL   Cell Tissue Res. 331:529-538(2008).
//
RX   PubMed=18050305; DOI=10.1002/gcc.20520;
RA   de Jong J., Stoop H., Gillis A.J.M., Hersmus R., van Gurp R.J.H.L.M.,
RA   van de Geijn G.-J.M., van Drunen E., Beverloo H.B., Schneider D.T.,
RA   Sherlock J.K., Baeten J., Kitazawa S., van Zoelen E.J.J.,
RA   van Roozendaal K., Oosterhuis J.W., Looijenga L.H.J.;
RT   "Further characterization of the first seminoma cell line TCam-2.";
RL   Genes Chromosomes Cancer 47:185-196(2008).
//
RX   PubMed=20607849; DOI=10.1002/gcc.20799;
RA   Goddard N.C., McIntyre A., Gilbert D.C., Kitazawa S., Shipley J.M.;
RT   "No evidence for V600E BRAF mutation in the seminoma cell line TCam-2.";
RL   Genes Chromosomes Cancer 49:963-966(2010).
//
RX   PubMed=21668453; DOI=10.1111/j.1365-2605.2011.01170.x;
RA   Young J.C., Jaiprakash A., Mithraprabhu S., Itman C., Kitazawa R.,
RA   Looijenga L.H.J., Loveland K.L.;
RT   "TCam-2 seminoma cell line exhibits characteristic foetal germ cell
RT   responses to TGF-beta ligands and retinoic acid.";
RL   Int. J. Androl. 34:e204-e217(2011).
//
RX   PubMed=23374840; DOI=10.1016/j.urology.2012.09.029; PMCID=PMC4179199;
RA   Russell S.M., Lechner M.G., Mokashi A.A., Megiel C., Jang J.K.,
RA   Taylor C.R., Looijenga L.H.J., French C.A., Epstein A.L.;
RT   "Establishment and characterization of a new human extragonadal germ
RT   cell line, SEM-1, and its comparison with TCam-2 and JKT-1.";
RL   Urology 81:464.e1-464.e9(2013).
//
RX   PubMed=24812411; DOI=10.1158/1078-0432.CCR-13-2868;
RA   Feldman D.R., Iyer G., Van Alstine L., Patil S., Al-Ahmadie H.,
RA   Reuter V.E., Bosl G.J., Chaganti R.S.K., Solit D.B.;
RT   "Presence of somatic mutations within PIK3CA, AKT, RAS, and FGFR3 but
RT   not BRAF in cisplatin-resistant germ cell tumors.";
RL   Clin. Cancer Res. 20:3712-3720(2014).
//
RX   PubMed=34153645; DOI=10.1016/j.neo.2021.05.008; PMCID=PMC8233172;
RA   Fink C., Baal N., Wilhelm J., Sarode P., Weigel R., Schumacher V.,
RA   Nettersheim D., Schorle H., Schrock C., Bergmann M., Kliesch S.,
RA   Kressin M., Savai R.;
RT   "On the origin of germ cell neoplasia in situ: dedifferentiation of
RT   human adult Sertoli cells in cross talk with seminoma cells in
RT   vitro.";
RL   Neoplasia 23:731-742(2021).
//
RX   PubMed=36899312; DOI=10.1186/s12885-023-10696-7; PMCID=PMC10007848;
RA   Schulz B., Schumacher V., Ngezahayo A., Maier-Begandt D., Schadzek N.,
RA   Wilhelm J., Weidner W., Pilatz A., Fietz D., Kliesch S., Schnepel N.,
RA   Hambruch N., Rode K., Langeheine M., Brehm R.;
RT   "Analysis of connexin 43, connexin 45 and N-cadherin in the human
RT   Sertoli cell line FS1 and the human seminoma-like cell line TCam-2 in
RT   comparison with human testicular biopsies.";
RL   BMC Cancer 23:232.1-232.20(2023).
//