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Cellosaurus HAP1 GABARAP (-) 3 (CVCL_SP34)

[Text version]
Cell line name HAP1 GABARAP (-) 3
Synonyms HZGHC003054c004; GABARAP knockout cell line 1bp deletion in exon 3
Accession CVCL_SP34
Resource Identification Initiative To cite this cell line use: HAP1 GABARAP (-) 3 (RRID:CVCL_SP34)
Comments Group: Haploid karyotype cell line.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:4067; GABARAP.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_Y019 (HAP1)
Sex of cell Male
Age at sampling 40Y
Category Cancer cell line
Publications

PubMed=30679523; DOI=10.1038/s41598-018-36717-1; PMCID=PMC6346085
Simons I.M., Mohrluder J., Feederle R., Kremmer E., Zobel T., Dobner J., Bleffert N., Hoffmann S., Willbold D.
The highly GABARAP specific rat monoclonal antibody 8H5 visualizes GABARAP in immunofluorescence imaging at endogenous levels.
Sci. Rep. 9:526-526(2019)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HZGHC003054c004
Cell line databases/resources cancercelllines; CVCL_SP34
Encyclopedic resources Wikidata; Q54874128
Entry history
Entry creation14-May-2018
Last entry update19-Dec-2024
Version number12