ID   GIST-T1/829
AC   CVCL_S983
DR   cancercelllines; CVCL_S983
DR   Cosmic; 1873952
DR   Wikidata; Q54835853
RX   PubMed=22665524;
RX   PubMed=25239608;
CC   Population: Japanese.
CC   Selected for resistance to: ChEBI; CHEBI:45783; Imatinib (Gleevec; STI571).
CC   Sequence variation: Mutation; HGNC; 6342; KIT; Simple; p.Val560_Tyr578del (c.1679_1735del); Zygosity=Heterozygous (PubMed=22665524).
CC   Sequence variation: Mutation; HGNC; 6342; KIT; Simple; p.Ala829Pro (c.2485G>C); ClinVar=VCV000375933; Zygosity=Heterozygous (PubMed=22665524).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
CC   Cell type: Interstitial cell of Cajal; CL=CL_0002088.
DI   NCIt; C3868; Gastrointestinal stromal tumor
DI   ORDO; Orphanet_44890; Gastrointestinal stromal tumor
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4976 ! GIST-T1
SX   Female
AG   47Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 30-01-24; Version: 15
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RX   PubMed=22665524; DOI=10.1158/1535-7163.MCT-12-0223;
RA   Heinrich M.C., Marino-Enriquez A., Presnell A., Donsky R.S.,
RA   Griffith D.J., McKinley A., Patterson J., Taguchi T., Liang C.-W.,
RA   Fletcher J.A.;
RT   "Sorafenib inhibits many kinase mutations associated with
RT   drug-resistant gastrointestinal stromal tumors.";
RL   Mol. Cancer Ther. 11:1770-1780(2012).
//
RX   PubMed=25239608; DOI=10.1158/1078-0432.CCR-14-1397;
RA   Garner A.P., Gozgit J.M., Anjum R., Vodala S., Schrock A.B., Zhou T.-J.,
RA   Serrano C., Eilers G., Zhu M.-J., Ketzer J., Wardwell S., Ning Y.,
RA   Song Y., Kohlmann A., Wang F., Clackson T., Heinrich M.C.,
RA   Fletcher J.A., Bauer S., Rivera V.M.;
RT   "Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and
RT   shows therapeutic potential in heavily pretreated gastrointestinal
RT   stromal tumor (GIST) patients.";
RL   Clin. Cancer Res. 20:5745-5755(2014).
//