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Cellosaurus NKNT-3 (CVCL_S905)

[Text version]
Cell line name NKNT-3
Accession CVCL_S905
Resource Identification Initiative To cite this cell line use: NKNT-3 (RRID:CVCL_S905)
Comments Group: Serum/protein free medium cell line.
Characteristics: The SV40 T antigen is flanked by LoxP recombination targets so that it can be excised by Cre/Lox site-specific recombination.
Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Transfected with: UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Cell type: Hepatocyte; CL=CL_0000182.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Adult
Category Transformed cell line

PubMed=10678831; DOI=10.1126/science.287.5456.1258
Kobayashi N., Fujiwara T., Westerman K.A., Inoue Y., Sakaguchi M., Noguchi H., Miyazaki M., Cai J., Tanaka N., Fox I.J., Leboulch P.
Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes.
Science 287:1258-1262(2000)

Kobayashi N., Noguchi H., Watanabe T., Matsumura T., Totsugawa T., Fujiwara T., Westerman K.A., Leboulch P., Fox I.J., Tanaka N.
Establishment of a tightly regulated human cell line for the development of hepatocyte transplantation.
Hum. Cell 13:7-13(2000)

PubMed=16970284; DOI=10.3727/000000006783981873
Hoekstra R., Deurholt T., ten Bloemendaal L., Desille M., van Wijk A.C.W.A., Clement B., Oude Elferink R.P.J., van Gulik T.M., Chamuleau R.A.F.M.
Assessment of in vitro applicability of reversibly immortalized NKNT-3 cells and clonal derivatives.
Cell Transplant. 15:423-433(2006)

Encyclopedic resources Wikidata; Q54930683
Entry history
Entry creation03-Feb-2014
Last entry update05-Oct-2023
Version number13