ID   402-91
AC   CVCL_S813
SY   402/91; MLS 402-91; MLS402
DR   EFO; EFO_0022655
DR   Cosmic; 1105011
DR   Cosmic; 1672267
DR   Cosmic; 2307719
DR   Cosmic; 2800529
DR   Wikidata; Q54602862
RX   PubMed=1283316;
RX   PubMed=16651630;
RX   PubMed=20515481;
RX   PubMed=24726063;
RX   PubMed=25393000;
RX   PubMed=26643872;
RX   PubMed=27270875;
RX   PubMed=30962207;
CC   Sequence variation: Gene fusion; HGNC; HGNC:2726; DDIT3 + HGNC; HGNC:4010; FUS; Name(s)=FUS-DDIT3, TLS-CHOP (PubMed=27270875).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=27270875).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Omics: SNP array analysis.
DI   NCIt; C27781; Myxoid liposarcoma
DI   ORDO; Orphanet_99967; Myxoid/round cell liposarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
CA   Transformed cell line
DT   Created: 03-02-14; Last updated: 19-12-24; Version: 17
//
RX   PubMed=1283316; DOI=10.1002/gcc.2870050403;
RA   Aman P., Ron D., Mandahl N., Fioretos T., Heim S., Arheden K.,
RA   Willen H., Rydholm A., Mitelman F.;
RT   "Rearrangement of the transcription factor gene CHOP in myxoid
RT   liposarcomas with t(12;16)(q13;p11).";
RL   Genes Chromosomes Cancer 5:278-285(1992).
//
RX   PubMed=16651630; DOI=10.2353/ajpath.2006.050872; PMCID=PMC1606602;
RA   Engstrom K., Willen H., Kabjorn-Gustafsson C., Andersson C.,
RA   Olsson M., Goransson M., Thelin-Jarnum S., Olofsson A., Warnhammar E.,
RA   Aman P.;
RT   "The myxoid/round cell liposarcoma fusion oncogene FUS-DDIT3 and the
RT   normal DDIT3 induce a liposarcoma phenotype in transfected human
RT   fibrosarcoma cells.";
RL   Am. J. Pathol. 168:1642-1653(2006).
//
RX   PubMed=20515481; DOI=10.1186/1471-2407-10-249; PMCID=PMC2889895;
RA   Andersson M.K., Goransson M., Olofsson A., Andersson C., Aman P.;
RT   "Nuclear expression of FLT1 and its ligand PGF in FUS-DDIT3 carrying
RT   myxoid liposarcomas suggests the existence of an intracrine signaling
RT   loop.";
RL   BMC Cancer 10:249.1-249.10(2010).
//
RX   PubMed=24726063; DOI=10.1186/1756-9966-33-33; PMCID=PMC4022359;
RA   Koelsche C., Renner M., Hartmann W., Brandt R., Lehner B.,
RA   Waldburger N., Alldinger I., Schmitt T., Egerer G., Penzel R.,
RA   Wardelmann E., Schirmacher P., von Deimling A., Mechtersheimer G.;
RT   "TERT promoter hotspot mutations are recurrent in myxoid liposarcomas
RT   but rare in other soft tissue sarcoma entities.";
RL   J. Exp. Clin. Cancer Res. 33:33.1-33.8(2014).
//
RX   PubMed=25393000; DOI=10.1371/journal.pone.0113110; PMCID=PMC4231113;
RA   Stahlberg A., Kabjorn-Gustafsson C., Engtrom K., Thomsen C.,
RA   Dolatabadi S., Jonasson E., Li C.-Y., Ruff D., Chen S.-M., Aman P.;
RT   "Normal and functional TP53 in genetically stable myxoid/round cell
RT   liposarcoma.";
RL   PLoS ONE 9:E113110-E113110(2014).
//
RX   PubMed=26643872; DOI=10.18632/oncotarget.6464; PMCID=PMC4767443;
RA   Kanojia D., Nagata Y., Garg M., Lee D.H., Sato A., Yoshida K.,
RA   Sato Y., Sanada M., Mayakonda A., Bartenhagen C., Klein H.-U.,
RA   Doan N.B., Said J.W., Mohith S., Gunasekar S., Shiraishi Y., Chiba K.,
RA   Tanaka H., Miyano S., Myklebost O., Yang H.H., Dugas M.,
RA   Meza-Zepeda L.A., Silberman A.W., Forscher C., Tyner J.W., Ogawa S.,
RA   Koeffler H.P.;
RT   "Genomic landscape of liposarcoma.";
RL   Oncotarget 6:42429-42444(2015).
//
RX   PubMed=27270875; DOI=10.1038/labinvest.2016.64; PMCID=PMC4965313;
RA   de Graaff M.A., Yu J.S.E., Beird H.C., Ingram D.R., Nguyen T.,
RA   Liu J.J.-H., Bolshakov S.V., Szuhai K., Aman P., Torres K.E., Lev D.C.,
RA   Nielsen T.O., Bovee J.V.M.G., Lazar A.J.F., Somaiah N.;
RT   "Establishment and characterization of a new human myxoid liposarcoma
RT   cell line (DL-221) with the FUS-DDIT3 translocation.";
RL   Lab. Invest. 96:885-894(2016).
//
RX   PubMed=30962207; DOI=10.15252/embr.201845766; PMCID=PMC6500973;
RA   Linden M., Thomsen C., Grundevik P., Jonasson E., Andersson D.,
RA   Runnberg R., Dolatabadi S., Vannas C., Santamaria M.L.,
RA   Fagman H., Stahlberg A., Aman P.;
RT   "FET family fusion oncoproteins target the SWI/SNF chromatin
RT   remodeling complex.";
RL   EMBO Rep. 20:e45766.1-e45766.15(2019).
//