Cellosaurus cell line HCC4011/R (CVCL

Cross-references
Cell line name	HCC4011/R
Synonyms	HCC4011/ER; HCC4011R
Accession	CVCL_S747
Resource Identification Initiative	To cite this cell line use: HCC4011/R (RRID:CVCL_S747)
Comments	Selected for resistance to: ChEBI; CHEBI_114785; Erlotinib.
Sequence variations	Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Unspecified (from parent cell line).
Disease	Lung adenocarcinoma (NCIt: C3512)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_S700 (HCC4011)
Sex of cell	Male
Age at sampling	53Y
Category	Cancer cell line
Publications	PubMed=22773810; DOI=10.1073/pnas.1203530109; PMCID=PMC3411967 Ohashi K., Sequist L.V., Arcila M.E., Moran T., Chmielecki J., Lin Y.-L., Pan Y.-M., Wang L., de Stanchina E., Shien K., Aoe K., Toyooka S., Kiura K., Fernandez-Cuesta L., Fidias P., Yang J.C.-H., Miller V.A., Riely G.J., Kris M.G., Engelman J.A., Vnencak-Jones C.L., Dias-Santagata D., Ladanyi M., Pao W. Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. Proc. Natl. Acad. Sci. U.S.A. 109:E2127-E2133(2012)
Cell line databases/resources	cancercelllines; CVCL_S747
Encyclopedic resources	Wikidata; Q54881734
Polymorphism and mutation databases	Cosmic; 1890458
Entry history
Entry creation	03-Feb-2014
Last entry update	19-Dec-2024
Version number	12