Cellosaurus cell line 11-18/R (CVCL

Cellosaurus 11-18/R (CVCL_S745)

Cross-references
Cell line name	11-18/R
Synonyms	11-18R; 11-18/ER
Accession	CVCL_S745
Resource Identification Initiative	To cite this cell line use: 11-18/R (RRID:CVCL_S745)
Comments	Population: Japanese and Micro. Selected for resistance to: ChEBI; CHEBI_114785; Erlotinib. Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations	Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Unspecified; Note=Acquired during resistance selection process (PubMed=22773810).
Disease	Lung adenocarcinoma (NCIt: C3512)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_6659 (11-18)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=22773810; DOI=10.1073/pnas.1203530109; PMCID=PMC3411967 Ohashi K., Sequist L.V., Arcila M.E., Moran T., Chmielecki J., Lin Y.-L., Pan Y.-M., Wang L., de Stanchina E., Shien K., Aoe K., Toyooka S., Kiura K., Fernandez-Cuesta L., Fidias P., Yang J.C.-H., Miller V.A., Riely G.J., Kris M.G., Engelman J.A., Vnencak-Jones C.L., Dias-Santagata D., Ladanyi M., Pao W. Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. Proc. Natl. Acad. Sci. U.S.A. 109:E2127-E2133(2012)
Cell line databases/resources	cancercelllines; CVCL_S745
Encyclopedic resources	Wikidata; Q54554912
Polymorphism and mutation databases	Cosmic; 1890459
Entry history
Entry creation	03-Feb-2014
Last entry update	19-Dec-2024
Version number	16