Cell line name |
p53HCT116 |
Synonyms |
P53HCT116; p53-/- HCT116; p53(-/-) HCT-116; HCT116-p53-/-; HCT116-p53 |
Accession |
CVCL_S744 |
Resource Identification Initiative |
To cite this cell line use: p53HCT116 (RRID:CVCL_S744) |
Comments |
Population: Caucasian. Knockout cell: Method=Gamma radiation; HGNC; HGNC:11998; TP53. Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
Sequence variations |
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Leu450Ter (c.1349delT) (p.Leu450fs) (c.1344delT); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
|
Disease |
Colon carcinoma (NCIt: C4910) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0291 (HCT 116) |
Sex of cell |
Male |
Age at sampling |
48Y |
Category |
Cancer cell line |
Publications | PubMed=9822382; DOI=10.1126/science.282.5393.1497 Bunz F., Dutriaux A., Lengauer C., Waldman T., Zhou S., Brown J.P., Sedivy J.M., Kinzler K.W., Vogelstein B. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282:1497-1501(1998) PubMed=19927377; DOI=10.1002/gcc.20730; PMCID=PMC2818350 Knutsen T., Padilla-Nash H.M., Wangsa D., Barenboim-Stapleton L., Camps J., McNeil N.E., Difilippantonio M.J., Ried T. Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines. Genes Chromosomes Cancer 49:204-223(2010) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_S744
SKY/M-FISH/CGH; 1688
SKY/M-FISH/CGH; 2781
|
Encyclopedic resources |
Wikidata; Q54937306
|
Polymorphism and mutation databases |
Cosmic; 1132690
|
Entry history |
Entry creation | 03-Feb-2014 |
Last entry update | 19-Dec-2024 |
Version number | 16 |
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