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Cellosaurus HCC827-GR-high1 (CVCL_S703)

[Text version]
Cell line name HCC827-GR-high1
Accession CVCL_S703
Resource Identification Initiative To cite this cell line use: HCC827-GR-high1 (RRID:CVCL_S703)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
Publications

PubMed=23542356; DOI=10.1158/0008-5472.CAN-12-4136; PMCID=PMC4506773
Shien K., Toyooka S., Yamamoto H., Soh J., Jida M., Thu K.L., Hashida S., Maki Y., Ichihara E., Asano H., Tsukuda K., Takigawa N., Kiura K., Gazdar A.F., Lam W.L., Miyoshi S.
Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells.
Cancer Res. 73:3051-3061(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S703
Encyclopedic resources Wikidata; Q54881800
Polymorphism and mutation databases Cosmic; 1896426
Entry history
Entry creation03-Feb-2014
Last entry update05-Oct-2023
Version number15