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Cellosaurus HCC4011-GR-step (CVCL_S702)

[Text version]
Cell line name HCC4011-GR-step
Accession CVCL_S702
Resource Identification Initiative To cite this cell line use: HCC4011-GR-step (RRID:CVCL_S702)
Comments Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Unspecified (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_S700 (HCC4011)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=23542356; DOI=10.1158/0008-5472.CAN-12-4136; PMCID=PMC4506773
Shien K., Toyooka S., Yamamoto H., Soh J., Jida M., Thu K.L., Hashida S., Maki Y., Ichihara E., Asano H., Tsukuda K., Takigawa N., Kiura K., Gazdar A.F., Lam W.L., Miyoshi S.
Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells.
Cancer Res. 73:3051-3061(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S702
Encyclopedic resources Wikidata; Q54881733
Polymorphism and mutation databases Cosmic; 1896432
Entry history
Entry creation03-Feb-2014
Last entry update05-Oct-2023
Version number11